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ADP-ribosylation factor GTPase activating protein 3
Protein ARFGAP3 PDB 2crw.png
PDB rendering based on 2crw.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM612439 MGI1913501 HomoloGene134103 GeneCards: ARFGAP3 Gene
RNA expression pattern
PBB GE ARFGAP3 202211 at tn.png
More reference expression data
Species Human Mouse
Entrez 26286 66251
Ensembl ENSG00000242247 ENSMUSG00000054277
UniProt Q9NP61 Q9D8S3
RefSeq (mRNA) NM_001142293 NM_025445
RefSeq (protein) NP_001135765 NP_079721
Location (UCSC) Chr 22:
43.19 – 43.25 Mb
Chr 15:
83.3 – 83.35 Mb
PubMed search [1] [2]

ADP-ribosylation factor GTPase-activating protein 3 is an enzyme that in humans is encoded by the ARFGAP3 gene.[1][2][3]

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.[3]


  1. ^ Zhang C, Yu Y, Zhang S, Liu M, Xing G, Wei H, Bi J, Liu X, Zhou G, Dong C, Hu Z, Zhang Y, Luo L, Wu C, Zhao S, He F (Jul 2000). "Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family". Genomics 63 (3): 400–8. doi:10.1006/geno.1999.6095. PMID 10704287. 
  2. ^ Liu X, Zhang C, Xing G, Chen Q, He F (Feb 2001). "Functional characterization of novel human ARFGAP3". FEBS Lett 490 (1-2): 79–83. doi:10.1016/S0014-5793(01)02134-2. PMID 11172815. 
  3. ^ a b "Entrez Gene: ARFGAP3 ADP-ribosylation factor GTPase activating protein 3". 

Further reading[edit]