ARHGAP1

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Rho GTPase activating protein 1
Protein ARHGAP1 PDB 1am4.png
PDB rendering based on 1am4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARHGAP1 ; CDC42GAP; RHOGAP; RHOGAP1; p50rhoGAP
External IDs OMIM602732 MGI2445003 HomoloGene20909 GeneCards: ARHGAP1 Gene
RNA expression pattern
PBB GE ARHGAP1 202117 at tn.png
PBB GE ARHGAP1 216689 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 392 228359
Ensembl ENSG00000175220 ENSMUSG00000027247
UniProt Q07960 Q5FWK3
RefSeq (mRNA) NM_004308 NM_001145902
RefSeq (protein) NP_004299 NP_001139374
Location (UCSC) Chr 11:
46.7 – 46.72 Mb
Chr 2:
91.65 – 91.67 Mb
PubMed search [1] [2]

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.[1][2]

Interactions[edit]

ARHGAP1 has been shown to interact with:

References[edit]

  1. ^ Lancaster CA, Taylor-Harris PM, Self AJ, Brill S, van Erp HE, Hall A (February 1994). "Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases". J Biol Chem 269 (2): 1137–42. PMID 8288572. 
  2. ^ "Entrez Gene: ARHGAP1 Rho GTPase activating protein 1". 
  3. ^ a b Low BC, Lim YP, Lim J, Wong ES, Guy GR (November 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46): 33123–30. doi:10.1074/jbc.274.46.33123. PMID 10551883. 
  4. ^ Low BC, Seow KT, Guy GR (December 2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48): 37742–51. doi:10.1074/jbc.M004897200. PMID 10954711. 
  5. ^ Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749. 
  6. ^ a b Li R, Zhang B, Zheng Y (December 1997). "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. 272 (52): 32830–5. doi:10.1074/jbc.272.52.32830. PMID 9407060. 
  7. ^ a b Zhang B, Chernoff J, Zheng Y (April 1998). "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA". J. Biol. Chem. 273 (15): 8776–82. doi:10.1074/jbc.273.15.8776. PMID 9535855. 
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  9. ^ Zhang B, Zheng Y (April 1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry 37 (15): 5249–57. doi:10.1021/bi9718447. PMID 9548756. 

Further reading[edit]