ARHGDIA

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Rho GDP dissociation inhibitor (GDI) alpha
Protein ARHGDIA PDB 1ajw.png
PDB rendering based on 1ajw.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARHGDIA ; GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1
External IDs OMIM601925 MGI2178103 HomoloGene908 GeneCards: ARHGDIA Gene
RNA expression pattern
PBB GE ARHGDIA 213606 s at tn.png
PBB GE ARHGDIA 201167 x at tn.png
PBB GE ARHGDIA 211716 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 396 192662
Ensembl ENSG00000141522 ENSMUSG00000025132
UniProt P52565 Q99PT1
RefSeq (mRNA) NM_001185077 NM_133796
RefSeq (protein) NP_001172006 NP_598557
Location (UCSC) Chr 17:
79.83 – 79.83 Mb
Chr 11:
120.58 – 120.58 Mb
PubMed search [1] [2]

Rho GDP-dissociation inhibitor 1 is a protein that in humans is encoded by the ARHGDIA gene.[1][2]

Interactions[edit]

ARHGDIA has been shown to interact with:

References[edit]

  1. ^ Wagner T, Tommerup N, Wirth J, Leffers H, Zimmer J, Back E et al. (July 1997). "A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3". Cytogenet Cell Genet 76 (3–4): 172–5. doi:10.1159/000134538. PMID 9186513. 
  2. ^ "Entrez Gene: ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha". 
  3. ^ a b c Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ a b c d Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (January 1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. doi:10.1016/s0014-5793(98)00020-9. PMID 9490022. 
  5. ^ a b c d Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie 83 (5): 409–14. doi:10.1016/s0300-9084(01)01263-9. PMID 11368848. 
  6. ^ Grizot S, Fauré J, Fieschi F, Vignais PV, Dagher MC, Pebay-Peyroula E (August 2001). "Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation". Biochemistry 40 (34): 10007–13. doi:10.1021/bi010288k. PMID 11513578. 
  7. ^ Lian LY, Barsukov I, Golovanov AP, Hawkins DI, Badii R, Sze KH et al. (January 2000). "Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure 8 (1): 47–55. doi:10.1016/s0969-2126(00)00080-0. PMID 10673424. 
  8. ^ Di-Poï N, Fauré J, Grizot S, Molnár G, Pick E, Dagher MC (August 2001). "Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex". Biochemistry 40 (34): 10014–22. doi:10.1021/bi010289c. PMID 11513579. 
  9. ^ Gajate C, Mollinedo F (March 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. 280 (12): 11641–7. doi:10.1074/jbc.M411781200. PMID 15659383. 
  10. ^ Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR (January 2001). "Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding". J. Cell Biol. 152 (1): 111–26. doi:10.1083/jcb.152.1.111. PMC 2193662. PMID 11149925. 
  11. ^ Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (February 2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function". Mol. Cell. Biol. 22 (4): 1158–71. doi:10.1128/mcb.22.4.1158-1171.2002. PMC 134637. PMID 11809807. 


Further reading[edit]

  • Leffers H, Nielsen MS, Andersen AH, Honoré B, Madsen P, Vandekerckhove J et al. (1994). "Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton". Exp. Cell Res. 209 (2): 165–74. doi:10.1006/excr.1993.1298. PMID 8262133. 
  • Keep NH, Barnes M, Barsukov I, Badii R, Lian LY, Segal AW et al. (1997). "A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm". Structure 5 (5): 623–33. doi:10.1016/S0969-2126(97)00218-9. PMID 9195882. 
  • Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S et al. (1997). "Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein". J. Biol. Chem. 272 (37): 23371–5. doi:10.1074/jbc.272.37.23371. PMID 9287351. 
  • Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. PMID 9490022. 
  • Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H et al. (1998). "Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl". Oncogene 16 (25): 3279–84. doi:10.1038/sj.onc.1201874. PMID 9681826. 
  • Newcombe AR, Stockley RW, Hunter JL, Webb MR (1999). "The interaction between rac1 and its guanine nucleotide dissociation inhibitor (GDI), monitored by a single fluorescent coumarin attached to GDI". Biochemistry 38 (21): 6879–86. doi:10.1021/bi9829837. PMID 10346909. 
  • Groysman M, Russek CS, Katzav S (2000). "Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation". FEBS Lett. 467 (1): 75–80. doi:10.1016/S0014-5793(00)01121-2. PMID 10664460. 
  • Lian LY, Barsukov I, Golovanov AP, Hawkins DI, Badii R, Sze KH et al. (2000). "Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure 8 (1): 47–55. doi:10.1016/S0969-2126(00)00080-0. PMID 10673424. 
  • Hoffman GR, Nassar N, Cerione RA (2000). "Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI". Cell 100 (3): 345–56. doi:10.1016/S0092-8674(00)80670-4. PMID 10676816. 
  • Matarrese P, Conti L, Varano B, Gauzzi MC, Belardelli F, Gessani S et al. (2000). "The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly". Cell Death Differ. 7 (1): 25–36. doi:10.1038/sj.cdd.4400616. PMID 10713718. 
  • Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR (2001). "Differential Localization of Rho Gtpases in Live Cells: Regulation by Hypervariable Regions and Rhogdi Binding". J. Cell Biol. 152 (1): 111–26. doi:10.1083/jcb.152.1.111. PMC 2193662. PMID 11149925. 
  • Longenecker KL, Garrard SM, Sheffield PJ, Derewenda ZS (2001). "Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 5): 679–88. doi:10.1107/S0907444901003122. PMID 11320308. 
  • Grizot S, Fauré J, Fieschi F, Vignais PV, Dagher MC, Pebay-Peyroula E (2001). "Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation". Biochemistry 40 (34): 10007–13. doi:10.1021/bi010288k. PMID 11513578. 
  • Di-Poï N, Fauré J, Grizot S, Molnár G, Pick E, Dagher MC (2001). "Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex". Biochemistry 40 (34): 10014–22. doi:10.1021/bi010289c. PMID 11513579. 
  • DerMardirossian C, Schnelzer A, Bokoch GM (2004). "Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase". Mol. Cell 15 (1): 117–27. doi:10.1016/j.molcel.2004.05.019. PMID 15225553. 
  • Dransart E, Morin A, Cherfils J, Olofsson B (2005). "Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors". J. Biol. Chem. 280 (6): 4674–83. doi:10.1074/jbc.M409741200. PMID 15513926. 
  • Gajate C, Mollinedo F (2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. 280 (12): 11641–7. doi:10.1074/jbc.M411781200. PMID 15659383.