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Rho GDP dissociation inhibitor (GDI) alpha
Protein ARHGDIA PDB 1ajw.png
PDB rendering based on 1ajw.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM601925 MGI2178103 HomoloGene908 GeneCards: ARHGDIA Gene
RNA expression pattern
PBB GE ARHGDIA 213606 s at tn.png
PBB GE ARHGDIA 201167 x at tn.png
PBB GE ARHGDIA 211716 x at tn.png
More reference expression data
Species Human Mouse
Entrez 396 192662
Ensembl ENSG00000141522 ENSMUSG00000025132
UniProt P52565 Q99PT1
RefSeq (mRNA) NM_001185077 NM_133796
RefSeq (protein) NP_001172006 NP_598557
Location (UCSC) Chr 17:
79.83 – 79.83 Mb
Chr 11:
120.58 – 120.58 Mb
PubMed search [1] [2]

Rho GDP-dissociation inhibitor 1 is a protein that in humans is encoded by the ARHGDIA gene.[1][2]


ARHGDIA has been shown to interact with RHOA,[3][4][5][6][7] CDC42,[3][6] RhoH,[7][8] RAC1[3][6][7][9][10][11] and Rac2.[6][7]


  1. ^ Wagner T, Tommerup N, Wirth J, Leffers H, Zimmer J, Back E, Weissenbach J, Scherer G (July 1997). "A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3". Cytogenet Cell Genet 76 (3–4): 172–5. doi:10.1159/000134538. PMID 9186513. 
  2. ^ "Entrez Gene: ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha". 
  3. ^ a b c Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ Gajate, Consuelo; Mollinedo Faustino (March 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. (United States) 280 (12): 11641–7. doi:10.1074/jbc.M411781200. ISSN 0021-9258. PMID 15659383. 
  5. ^ Michaelson, D; Silletti J; Murphy G; D'Eustachio P; Rush M; Philips M R (January 2001). "Differential Localization of Rho Gtpases in Live Cells: Regulation by Hypervariable Regions and Rhogdi Binding". J. Cell Biol. (United States) 152 (1): 111–26. doi:10.1083/jcb.152.1.111. ISSN 0021-9525. PMC 2193662. PMID 11149925. 
  6. ^ a b c d Gorvel, J P; Chang T C; Boretto J; Azuma T; Chavrier P (January 1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. (NETHERLANDS) 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. ISSN 0014-5793. PMID 9490022. 
  7. ^ a b c d Fauré, J; Dagher M C (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie (France) 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. ISSN 0300-9084. PMID 11368848. 
  8. ^ Li, Xiaoyu; Bu Xia; Lu Binfeng; Avraham Hava; Flavell Richard A; Lim Bing (February 2002). "The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol. (United States) 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. ISSN 0270-7306. PMC 134637. PMID 11809807. 
  9. ^ Grizot, S; Fauré J; Fieschi F; Vignais P V; Dagher M C; Pebay-Peyroula E (August 2001). "Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation". Biochemistry (United States) 40 (34): 10007–13. doi:10.1021/bi010288k. ISSN 0006-2960. PMID 11513578. 
  10. ^ Lian, L Y; Barsukov I; Golovanov A P; Hawkins D I; Badii R; Sze K H; Keep N H; Bokoch G M; Roberts G C (January 2000). "Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure (ENGLAND) 8 (1): 47–55. doi:10.1016/S0969-2126(00)00080-0. ISSN 0969-2126. PMID 10673424. 
  11. ^ Di-Poï, N; Fauré J; Grizot S; Molnár G; Pick E; Dagher M C (August 2001). "Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex". Biochemistry (United States) 40 (34): 10014–22. doi:10.1021/bi010289c. ISSN 0006-2960. PMID 11513579. 

Further reading[edit]