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Rho guanine nucleotide exchange factor (GEF) 1
Protein ARHGEF1 PDB 1iap.png
PDB rendering based on 1iap.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARHGEF1 ; GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5
External IDs OMIM601855 MGI1353510 HomoloGene3454 GeneCards: ARHGEF1 Gene
RNA expression pattern
PBB GE ARHGEF1 203055 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9138 16801
Ensembl ENSG00000076928 ENSMUSG00000040940
UniProt Q92888 Q61210
RefSeq (mRNA) NM_004706 NM_001130150
RefSeq (protein) NP_004697 NP_001123622
Location (UCSC) Chr 19:
42.39 – 42.43 Mb
Chr 7:
24.9 – 24.93 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.[1][2][3]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[3]


ARHGEF1 has been shown to interact with GNA13,[4][5][6] CD44,[4] P110α[7] and GNA12.[4]


  1. ^ Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G (Nov 1996). "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". J Biol Chem 271 (41): 25452–8. doi:10.1074/jbc.271.41.25452. PMID 8810315. 
  2. ^ Aasheim HC, Pedeutour F, Smeland EB (May 1997). "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues". Oncogene 14 (14): 1747–52. doi:10.1038/sj.onc.1200994. PMID 9135076. 
  3. ^ a b "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1". 
  4. ^ a b c
  5. ^ Bhattacharyya, Raja; Wedegaertner Philip B (Apr 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. (Netherlands) 540 (1–3): 211–6. doi:10.1016/S0014-5793(03)00267-9. ISSN 0014-5793. PMID 12681510. 
  6. ^ Hart, M J; Jiang X; Kozasa T; Roscoe W; Singer W D; Gilman A G; Sternweis P C; Bollag G (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science (UNITED STATES) 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. ISSN 0036-8075. PMID 9641916. 
  7. ^ Holinstat, Michael; Mehta Dolly; Kozasa Tohru; Minshall Richard D; Malik Asrar B (Aug 2003). "Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement". J. Biol. Chem. (United States) 278 (31): 28793–8. doi:10.1074/jbc.M303900200. ISSN 0021-9258. PMID 12754211. 

Further reading[edit]