ARHGEF1

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Rho guanine nucleotide exchange factor (GEF) 1
Protein ARHGEF1 PDB 1iap.png
PDB rendering based on 1iap.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARHGEF1 ; GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5
External IDs OMIM601855 MGI1353510 HomoloGene3454 GeneCards: ARHGEF1 Gene
RNA expression pattern
PBB GE ARHGEF1 203055 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9138 16801
Ensembl ENSG00000076928 ENSMUSG00000040940
UniProt Q92888 Q61210
RefSeq (mRNA) NM_004706 NM_001130150
RefSeq (protein) NP_004697 NP_001123622
Location (UCSC) Chr 19:
42.39 – 42.43 Mb
Chr 7:
24.9 – 24.93 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.[1][2][3]

Function[edit]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[3]

Interactions[edit]

ARHGEF1 has been shown to interact with:

References[edit]

  1. ^ Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P et al. (Nov 1996). "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". J Biol Chem 271 (41): 25452–8. doi:10.1074/jbc.271.41.25452. PMID 8810315. 
  2. ^ Aasheim HC, Pedeutour F, Smeland EB (May 1997). "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues". Oncogene 14 (14): 1747–52. doi:10.1038/sj.onc.1200994. PMID 9135076. 
  3. ^ a b "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1". 
  4. ^ a b c Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T et al. "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nat. Cell Biol. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662. 
  5. ^ Bhattacharyya R, Wedegaertner PB (Apr 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. 540 (1-3): 211–6. doi:10.1016/s0014-5793(03)00267-9. PMID 12681510. 
  6. ^ Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG et al. (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916. 
  7. ^ Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB (Aug 2003). "Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement". J. Biol. Chem. 278 (31): 28793–8. doi:10.1074/jbc.M303900200. PMID 12754211. 


Further reading[edit]

  • Fukuhara S, Chikumi H, Gutkind JS (2001). "RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?". Oncogene 20 (13): 1661–8. doi:10.1038/sj.onc.1204182. PMID 11313914. 
  • Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG et al. (1998). "p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13". Science 280 (5372): 2109–11. doi:10.1126/science.280.5372.2109. PMID 9641915. 
  • Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG et al. (1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916. 
  • Zhang H, Wang L, Kao S, Whitehead IP, Hart MJ, Liu B et al. (1999). "Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF". Curr. Biol. 9 (21): 1271–4. doi:10.1016/S0960-9822(99)80511-9. PMID 10556093. 
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806. 
  • Bhattacharyya R, Wedegaertner PB (2000). "Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding". J. Biol. Chem. 275 (20): 14992–9. doi:10.1074/jbc.M000415200. PMID 10747909. 
  • Kozasa T (2001). "Regulation of G protein-mediated signal transduction by RGS proteins". Life Sci. 68 (19–20): 2309–17. doi:10.1016/S0024-3205(01)01020-7. PMID 11358341. 
  • Wells CD, Gutowski S, Bollag G, Sternweis PC (2001). "Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor". J. Biol. Chem. 276 (31): 28897–905. doi:10.1074/jbc.M102913200. PMID 11384980. 
  • Chen Z, Wells CD, Sternweis PC, Sprang SR (2001). "Structure of the rgRGS domain of p115RhoGEF". Nat. Struct. Biol. 8 (9): 805–9. doi:10.1038/nsb0901-805. PMID 11524686. 
  • Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P et al. (2003). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917. 
  • Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Lett. 529 (2–3): 168–72. doi:10.1016/S0014-5793(02)03323-9. PMID 12372594. 
  • Chen Z, Singer WD, Wells CD, Sprang SR, Sternweis PC (2003). "Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF". J. Biol. Chem. 278 (11): 9912–9. doi:10.1074/jbc.M212695200. PMID 12525488. 
  • Bhattacharyya R, Wedegaertner PB (2003). "Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF". Biochem. J. 371 (Pt 3): 709–20. doi:10.1042/BJ20021897. PMC 1223324. PMID 12534370. 
  • Bhattacharyya R, Wedegaertner PB (2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. 540 (1–3): 211–6. doi:10.1016/S0014-5793(03)00267-9. PMID 12681510. 
  • Bourguignon LY, Singleton PA, Zhu H, Diedrich F (2003). "Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression". J. Biol. Chem. 278 (32): 29420–34. doi:10.1074/jbc.M301885200. PMID 12748184. 
  • Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB (2003). "Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement". J. Biol. Chem. 278 (31): 28793–8. doi:10.1074/jbc.M303900200. PMID 12754211.