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Rho guanine nucleotide exchange factor (GEF) 11
Protein ARHGEF11 PDB 1htj.png
PDB rendering based on 1htj.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605708 MGI2441869 HomoloGene11409 GeneCards: ARHGEF11 Gene
RNA expression pattern
PBB GE ARHGEF11 202913 at tn.png
PBB GE ARHGEF11 202914 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9826 213498
Ensembl ENSG00000132694 ENSMUSG00000041977
UniProt O15085 D6RGQ8
RefSeq (mRNA) NM_014784 NM_001003912
RefSeq (protein) NP_055599 NP_001003912
Location (UCSC) Chr 1:
156.9 – 157.02 Mb
Chr 3:
87.62 – 87.74 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene.[1][2][3]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.[3]


ARHGEF11 has been shown to interact with PLXNB3,[4][5] PLXNB1,[4][5][6][7] PLXNB2[4][5] and RHOA.[1]


  1. ^ a b Rumenapp U, Blomquist A, Schworer G, Schablowski H, Psoma A, Jakobs KH (Nov 1999). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member". FEBS Lett 459 (3): 313–8. doi:10.1016/S0014-5793(99)01270-3. PMID 10526156. 
  2. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  3. ^ a b "Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11". 
  4. ^ a b c Perrot, Valerie; Vazquez-Prado Jose, Gutkind J Silvio (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. (United States) 277 (45): 43115–20. doi:10.1074/jbc.M206005200. ISSN 0021-9258. PMID 12183458. 
  5. ^ a b c Swiercz, Jakub M; Kuner Rohini; Behrens Jürgen; Offermanns Stefan (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron (United States) 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. ISSN 0896-6273. PMID 12123608. 
  6. ^ Oinuma, Izumi; Katoh Hironori; Harada Amane; Negishi Manabu (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. (United States) 278 (28): 25671–7. doi:10.1074/jbc.M303047200. ISSN 0021-9258. PMID 12730235. 
  7. ^ Hirotani, Mutsumi; Ohoka Yoshiharu; Yamamoto Takahiro; Nirasawa Hiromi; Furuyama Tatsuo; Kogo Mikihiko; Matsuya Tokuzo; Inagaki Shinobu (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. (United States) 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. ISSN 0006-291X. PMID 12220504. 

Further reading[edit]