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Rho guanine nucleotide exchange factor (GEF) 12
Protein ARHGEF12 PDB 1txd.png
PDB rendering based on 1txd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARHGEF12 ; LARG; PRO2792
External IDs OMIM604763 MGI1916882 HomoloGene9088 GeneCards: ARHGEF12 Gene
RNA expression pattern
PBB GE ARHGEF12 201333 s at tn.png
PBB GE ARHGEF12 201334 s at tn.png
PBB GE ARHGEF12 201335 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23365 69632
Ensembl ENSG00000196914 ENSMUSG00000059495
UniProt Q9NZN5 Q8R4H2
RefSeq (mRNA) NM_001198665 NM_027144
RefSeq (protein) NP_001185594 NP_081420
Location (UCSC) Chr 11:
120.21 – 120.36 Mb
Chr 9:
42.96 – 43.11 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.[1][2][3]


Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.[3]

Clinical significance[edit]

This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.[3]


ARHGEF12 has been shown to interact with:


  1. ^ Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA (April 2000). "Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia". Proc Natl Acad Sci U S A 97 (5): 2145–50. doi:10.1073/pnas.040569197. PMC 15768. PMID 10681437. 
  2. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  3. ^ a b c "Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12". 
  4. ^ a b Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. 485 (2-3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164. 
  5. ^ a b c d Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866. 
  6. ^ Taya S, Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (November 2001). "Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF". J. Cell Biol. 155 (5): 809–20. doi:10.1083/jcb.200106139. PMC 2150867. PMID 11724822. 
  7. ^ Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (September 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504. 
  8. ^ Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ (July 2001). "Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA". J. Biol. Chem. 276 (29): 27145–51. doi:10.1074/jbc.M103565200. PMID 11373293. 

Further reading[edit]