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Rho guanine nucleotide exchange factor (GEF) 5
Symbols ARHGEF5 ; GEF5; P60; TIM; TIM1
External IDs OMIM600888 MGI1858952 HomoloGene66300 GeneCards: ARHGEF5 Gene
RNA expression pattern
PBB GE ARHGEF5 204765 at tn.png
More reference expression data
Species Human Mouse
Entrez 7984 54324
Ensembl ENSG00000050327 ENSMUSG00000033542
UniProt Q12774 n/a
RefSeq (mRNA) NM_001002861 NM_133674
RefSeq (protein) NP_005426 NP_598435
Location (UCSC) Chr 7:
144.05 – 144.08 Mb
Chr 6:
43.27 – 43.29 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.[1][2][3]

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.[3]


  1. ^ Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T (Apr 1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Oncogene 9 (4): 1057–63. PMID 8134109. 
  2. ^ Takai S, Chan AM, Yamada K, Miki T (Oct 1995). "Assignment of the human TIM proto-oncogene to 7q33→q35". Cancer Genet Cytogenet 83 (1): 87–9. doi:10.1016/S0165-4608(95)00017-8. PMID 7656213. 
  3. ^ a b "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5". 

Further reading[edit]