ARHGEF6

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Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Protein ARHGEF6 PDB 1ujy.png
PDB rendering based on 1ujy.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARHGEF6 ; COOL2; Cool-2; MRX46; PIXA; alpha-PIX; alphaPIX
External IDs OMIM300267 MGI1920591 HomoloGene3561 GeneCards: ARHGEF6 Gene
RNA expression pattern
PBB GE ARHGEF6 209539 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9459 73341
Ensembl ENSG00000129675 ENSMUSG00000031133
UniProt Q15052 Q8K4I3
RefSeq (mRNA) NM_004840 NM_152801
RefSeq (protein) NP_004831 NP_690014
Location (UCSC) Chr X:
135.75 – 135.86 Mb
Chr X:
57.23 – 57.34 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.[1][2][3]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.[3]

References[edit]

  1. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)". DNA Res 1 (5): 251–62. doi:10.1093/dnares/1.5.251. PMID 7584048. 
  2. ^ Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L (Jul 1998). "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors". Mol Cell 1 (2): 183–92. doi:10.1016/S1097-2765(00)80019-2. PMID 9659915. 
  3. ^ a b "Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6". 

Further reading[edit]