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Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Protein ARHGEF6 PDB 1ujy.png
PDB rendering based on 1ujy.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARHGEF6 ; COOL2; Cool-2; MRX46; PIXA; alpha-PIX; alphaPIX
External IDs OMIM300267 MGI1920591 HomoloGene3561 GeneCards: ARHGEF6 Gene
RNA expression pattern
PBB GE ARHGEF6 209539 at tn.png
More reference expression data
Species Human Mouse
Entrez 9459 73341
Ensembl ENSG00000129675 ENSMUSG00000031133
UniProt Q15052 Q8K4I3
RefSeq (mRNA) NM_004840 NM_152801
RefSeq (protein) NP_004831 NP_690014
Location (UCSC) Chr X:
135.75 – 135.86 Mb
Chr X:
57.23 – 57.34 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.[1][2][3]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.[3]


  1. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)". DNA Res 1 (5): 251–62. doi:10.1093/dnares/1.5.251. PMID 7584048. 
  2. ^ Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L (Jul 1998). "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors". Mol Cell 1 (2): 183–92. doi:10.1016/S1097-2765(00)80019-2. PMID 9659915. 
  3. ^ a b "Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6". 

Further reading[edit]