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Rho guanine nucleotide exchange factor (GEF) 7
Protein ARHGEF7 PDB 1by1.png
PDB rendering based on 1by1.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARHGEF7 ; BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB
External IDs OMIM605477 MGI1860493 HomoloGene2895 GeneCards: ARHGEF7 Gene
RNA expression pattern
PBB GE ARHGEF7 202548 s at tn.png
PBB GE ARHGEF7 202547 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8874 54126
Ensembl ENSG00000102606 ENSMUSG00000031511
UniProt Q14155 Q9ES28
RefSeq (mRNA) NM_001113511 NM_001113517
RefSeq (protein) NP_001106983 NP_001106989
Location (UCSC) Chr 13:
111.77 – 111.96 Mb
Chr 8:
11.73 – 11.84 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.[1][2][3]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.[3]


ARHGEF7 has been shown to interact with GIT1,[4][5] SHANK3,[6] Cbl gene,[7] SHANK1[6] and SHANK2.[6]


  1. ^ Oh WK, Yoo JC, Jo D, Song YH, Kim MG, Park D (Jul 1997). "Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion". Biochem Biophys Res Commun 235 (3): 794–8. doi:10.1006/bbrc.1997.6875. PMID 9207241. 
  2. ^ Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L, Cerione RA (Oct 1998). "A novel regulator of p21-activated kinases". J Biol Chem 273 (37): 23633–6. doi:10.1074/jbc.273.37.23633. PMID 9726964. 
  3. ^ a b "Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7". 
  4. ^ Kim, Seho; Ko Jaewon, Shin Hyewon, Lee Jae-Ran, Lim Chunghun, Han Jin-Hee, Altrock Wilko D, Garner Craig C, Gundelfinger Eckart D, Premont Richard T, Kaang Bong-Kiun, Kim Eunjoon (Feb 2003). "The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo". J. Biol. Chem. (United States) 278 (8): 6291–300. doi:10.1074/jbc.M212287200. ISSN 0021-9258. PMID 12473661. 
  5. ^ Bagrodia, S; Bailey D; Lenard Z; Hart M; Guan J L; Premont R T; Taylor S J; Cerione R A (Aug 1999). "A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins". J. Biol. Chem. (UNITED STATES) 274 (32): 22393–400. doi:10.1074/jbc.274.32.22393. ISSN 0021-9258. PMID 10428811. 
  6. ^ a b c Park, Eunhye; Na Moonseok; Choi Jeonghoon; Kim Seho; Lee Jae-Ran; Yoon Jiyoung; Park Dongeun; Sheng Morgan; Kim Eunjoon (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. (United States) 278 (21): 19220–9. doi:10.1074/jbc.M301052200. ISSN 0021-9258. PMID 12626503. 
  7. ^ Flanders, James A; Feng Qiyu; Bagrodia Shubha; Laux Maria T; Singavarapu Avinash; Cerione Richard A (Aug 2003). "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. (Netherlands) 550 (1–3): 119–23. doi:10.1016/S0014-5793(03)00853-6. ISSN 0014-5793. PMID 12935897. 

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