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Cdc42 guanine nucleotide exchange factor (GEF) 9
Protein ARHGEF9 PDB 2dfk.png
PDB rendering based on 2dfk.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM300429 MGI2442233 HomoloGene9053 GeneCards: ARHGEF9 Gene
RNA expression pattern
PBB GE ARHGEF9 203263 s at tn.png
PBB GE ARHGEF9 203264 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23229 236915
Ensembl ENSG00000131089 ENSMUSG00000025656
UniProt O43307 Q3UTH8
RefSeq (mRNA) NM_001173479 NM_001033329
RefSeq (protein) NP_001166950 NP_001028501
Location (UCSC) Chr HG1437_PATCH:
62.85 – 63.01 Mb
Chr X:
95.05 – 95.2 Mb
PubMed search [1] [2]

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.[1][2][3]

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM][3]


ARHGEF9 has been shown to interact with GPHN[4] and SMURF1.[5]


  1. ^ Reid T, Bathoorn A, Ahmadian MR, Collard JG (Dec 1999). "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem 274 (47): 33587–93. doi:10.1074/jbc.274.47.33587. PMID 10559246. 
  2. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477. 
  3. ^ a b "Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9". 
  4. ^
  5. ^ Yamaguchi, Kei; Ohara Osamu; Ando Akikazu; Nagase Takahiro (Apr 2008). "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. (Germany) 389 (4): 405–13. doi:10.1515/BC.2008.036. ISSN 1431-6730. PMID 18208356. 

Further reading[edit]