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Ariadne RBR E3 ubiquitin protein ligase 1
Protein ARIH1 PDB 1wd2.png
PDB rendering based on 1wd2.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605624 MGI1344363 HomoloGene111871 GeneCards: ARIH1 Gene
RNA expression pattern
PBB GE ARIH1 201878 at tn.png
PBB GE ARIH1 201879 at tn.png
PBB GE ARIH1 201881 s at tn.png
More reference expression data
Species Human Mouse
Entrez 25820 23806
Ensembl ENSG00000166233 ENSMUSG00000025234
UniProt Q9Y4X5 Q9Z1K5
RefSeq (mRNA) NM_005744 NM_019927
RefSeq (protein) NP_005735 NP_064311
Location (UCSC) Chr 15:
72.77 – 72.88 Mb
Chr 9:
59.39 – 59.49 Mb
PubMed search [1] [2]

Protein ariadne-1 homolog is a protein that in humans is encoded by the ARIH1 gene.[1][2]


ARIH1 has been shown to interact with:


  1. ^ a b Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (November 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492. 
  2. ^ "Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)". 
  3. ^ a b Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/s0014-5793(03)01235-3. PMID 14623119. 
  4. ^ Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (June 2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi:10.1074/jbc.M011028200. PMID 11278816. 

Further reading[edit]