ARL2

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ADP-ribosylation factor-like 2
Protein ARL2 PDB 1ksg.png
PDB rendering based on 1ksg.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARL2 ; ARFL2
External IDs OMIM601175 MGI1928393 HomoloGene1260 GeneCards: ARL2 Gene
Orthologs
Species Human Mouse
Entrez 402 56327
Ensembl ENSG00000213465 ENSMUSG00000024944
UniProt P36404 Q9D0J4
RefSeq (mRNA) NM_001199745 NM_019722
RefSeq (protein) NP_001186674 NP_062696
Location (UCSC) Chr 11:
64.78 – 64.79 Mb
Chr 19:
6.13 – 6.14 Mb
PubMed search [1] [2]

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.[1][2][3]

The ADP-ribosylation factor (ARF) genes are small GTP-binding proteins of the RAS superfamily. ARL2 is a member of a functionally distinct group of ARF-like genes.[3]

Interactions[edit]

ARL2 has been shown to interact with Protein unc-119 homolog,[4] TBCD[5][6] and PDE6D.[7][8]

References[edit]

  1. ^ Clark J, Moore L, Krasinskas A, Way J, Battey J, Tamkun J, Kahn RA (November 1993). "Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes". Proc Natl Acad Sci U S A 90 (19): 8952–6. doi:10.1073/pnas.90.19.8952. PMC 47479. PMID 8415637. 
  2. ^ Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (September 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601. 
  3. ^ a b "Entrez Gene: ARL2 ADP-ribosylation factor-like 2". 
  4. ^ Kobayashi, Akira; Kubota Shinya; Mori Naoki; McLaren Margaret J; Inana George (January 2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. (Netherlands) 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. ISSN 0014-5793. PMID 12527357. 
  5. ^ Shern, Jack F; Sharer J Daniel; Pallas David C; Bartolini Francesca; Cowan Nicholas J; Reed Matthew S; Pohl Jan; Kahn Richard A (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. (United States) 278 (42): 40829–36. doi:10.1074/jbc.M308678200. ISSN 0021-9258. PMID 12912990. 
  6. ^ Bhamidipati, A; Lewis S A; Cowan N J (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. (UNITED STATES) 149 (5): 1087–96. doi:10.1083/jcb.149.5.1087. ISSN 0021-9525. PMC 2174823. PMID 10831612. 
  7. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ Hanzal-Bayer, Michael; Renault Louis; Roversi Pietro; Wittinghofer Alfred; Hillig Roman C (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. (England) 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. ISSN 0261-4189. PMC 125981. PMID 11980706. 

Further reading[edit]