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ADP-ribosylation factor-like 3
Protein ARL3 PDB 1fzq.png
PDB rendering based on 1fzq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARL3 ; ARFL3
External IDs OMIM604695 MGI1929699 HomoloGene48276 GeneCards: ARL3 Gene
RNA expression pattern
PBB GE ARL3 202641 at tn.png
PBB GE ARL3 213433 at tn.png
More reference expression data
Species Human Mouse
Entrez 403 56350
Ensembl ENSG00000138175 ENSMUSG00000025035
UniProt P36405 Q9WUL7
RefSeq (mRNA) NM_004311 NM_019718
RefSeq (protein) NP_004302 NP_062692
Location (UCSC) Chr 10:
104.44 – 104.47 Mb
Chr 19:
46.53 – 46.57 Mb
PubMed search [1] [2]

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.[1][2][3]

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.[3]


ARL3 has been shown to interact with Protein unc-119 homolog.[4][5]


  1. ^ Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA (August 1994). "ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues". J Biol Chem 269 (29): 18937–42. PMID 8034651. 
  2. ^ Kim HS (March 1999). "Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping". Cytogenet Cell Genet 83 (3-4): 246. doi:10.1159/000015194. PMID 10072593. 
  3. ^ a b "Entrez Gene: ARL3 ADP-ribosylation factor-like 3". 
  4. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 
  5. ^ Van Valkenburgh, H; Shern J F; Sharer J D; Zhu X; Kahn R A (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. (United States) 276 (25): 22826–37. doi:10.1074/jbc.M102359200. ISSN 0021-9258. PMID 11303027. 

Further reading[edit]