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ADP-ribosylation factor-like 4A
Symbols ARL4A ; ARL4
External IDs OMIM604786 MGI99437 HomoloGene4194 GeneCards: ARL4A Gene
RNA expression pattern
PBB GE ARL4A 205020 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10124 11861
Ensembl ENSG00000122644 ENSMUSG00000047446
UniProt P40617 P61213
RefSeq (mRNA) NM_001037164 NM_001039515
RefSeq (protein) NP_001032241 NP_001034604
Location (UCSC) Chr 7:
12.73 – 12.73 Mb
Chr 12:
40.01 – 40.04 Mb
PubMed search [1] [2]

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.[1]

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.[1]


ARL4A has been shown to interact with Karyopherin alpha 2.[2]


  1. ^ a b "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A". 
  2. ^ Lin, C Y; Huang P H; Liao W L; Cheng H J; Huang C F; Kuo J C; Patton W A; Massenburg D; Moss J; Lee F J (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. (UNITED STATES) 275 (48): 37815–23. doi:10.1074/jbc.M002470200. ISSN 0021-9258. PMID 10980193. 

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