ARMS2

Age-related maculopathy susceptibility 2
Identifiers
Symbols	ARMS2;
External IDs	OMIM: 611313 HomoloGene: 88167 GeneCards: ARMS2 Gene
Gene Ontology Cellular component • photoreceptor inner segment • cytoplasm • mitochondrion Biological process • retina homeostasis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	387715	n/a
Ensembl	ENSG00000254636	n/a
UniProt	P0C7Q2	n/a
RefSeq (mRNA)	XM_001131263	n/a
RefSeq (protein)	XP_001131263	n/a
Location (UCSC)	Chr 10: 124.21 – 124.22 Mb	n/a
PubMed search	[1]	n/a

Age-related maculopathy susceptibility protein 2, mitochondrial is a protein that in humans is encoded by the ARMS2 gene.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Schmidt S, Hauser MA, Scott WK, et al. (2006). "Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.". Am. J. Hum. Genet. 78 (5): 852–64. doi:10.1086/503822. PMC 1474047. PMID 16642439. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1474047. 
• Shastry BS (2006). "Further support for the common variants in complement factor H (Y402H) and LOC387715 (A69S) genes as major risk factors for the exudative age-related macular degeneration.". Ophthalmologica 220 (5): 291–5. doi:10.1159/000094617. PMID 16954704. 
• Conley YP, Jakobsdottir J, Mah T, et al. (2006). "CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses.". Hum. Mol. Genet. 15 (21): 3206–18. doi:10.1093/hmg/ddl396. PMID 17000705. 
• Tanimoto S, Tamura H, Ue T, et al. (2007). "A polymorphism of LOC387715 gene is associated with age-related macular degeneration in the Japanese population.". Neurosci. Lett. 414 (1): 71–4. doi:10.1016/j.neulet.2006.12.011. PMID 17194541. 
• Shastry BS (2007). "Assessment of the contribution of the LOC387715 gene polymorphism in a family with exudative age-related macular degeneration and heterozygous CFH variant (Y402H).". J. Hum. Genet. 52 (4): 384–7. doi:10.1007/s10038-007-0120-y. PMID 17285240. 
• Ross RJ, Bojanowski CM, Wang JJ, et al. (2007). "The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples.". Invest. Ophthalmol. Vis. Sci. 48 (3): 1128–32. doi:10.1167/iovs.06-0999. PMC 1885234. PMID 17325155. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1885234. 
• Francis PJ, George S, Schultz DW, et al. (2007). "The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration.". Hum. Hered. 63 (3-4): 212–8. doi:10.1159/000100046. PMID 17347568. 
• Chen D, Langford MP, Duggan C, et al. (2007). "Expression of recombinant protein encoded by LOC387715 in Escherichia coli.". Protein Expr. Purif. 54 (2): 275–82. doi:10.1016/j.pep.2007.03.017. PMC 2780029. PMID 17485225. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2780029. 
• Kondo N, Honda S, Ishibashi K, et al. (2007). "LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population.". Am. J. Ophthalmol. 144 (4): 608–12. doi:10.1016/j.ajo.2007.06.003. PMID 17692272. 
• Wiggs JL (2007). "Macular degeneration: risk factors for progression.". Arch. Ophthalmol. 125 (9): 1264–5. doi:10.1001/archopht.125.9.1264. PMID 17846368. 
• Kanda A, Chen W, Othman M, et al. (2007). "A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.". Proc. Natl. Acad. Sci. U.S.A. 104 (41): 16227–32. doi:10.1073/pnas.0703933104. PMC 1987388. PMID 17884985. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1987388. 
• Brantley MA, Fang AM, King JM, et al. (2007). "Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab.". Ophthalmology 114 (12): 2168–73. doi:10.1016/j.ophtha.2007.09.008. PMID 18054635.