ARNT2

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Aryl-hydrocarbon receptor nuclear translocator 2
Identifiers
Symbols ARNT2 ; bHLHe1
External IDs OMIM606036 MGI107188 HomoloGene7230 GeneCards: ARNT2 Gene
RNA expression pattern
PBB GE ARNT2 202986 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9915 11864
Ensembl ENSG00000172379 ENSMUSG00000015709
UniProt Q9HBZ2 Q61324
RefSeq (mRNA) NM_014862 NM_007488
RefSeq (protein) NP_055677 NP_031514
Location (UCSC) Chr 15:
80.7 – 80.89 Mb
Chr 7:
84.25 – 84.41 Mb
PubMed search [1] [2]

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.[1][2]

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.[2]

References[edit]

  1. ^ Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670. 
  2. ^ a b "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2". 

Further reading[edit]