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N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B
Symbols ASAH2B ; ASAH2C; ASAH2L; bA449O16.3
External IDs OMIM610987 IUPHAR: 2493 GeneCards: ASAH2B Gene
EC number
Species Human Mouse
Entrez 653308 n/a
Ensembl ENSG00000204147 n/a
UniProt P0C7U1 n/a
RefSeq (mRNA) NM_001079516 n/a
RefSeq (protein) NP_001072984 n/a
Location (UCSC) Chr 10:
52.5 – 52.58 Mb
PubMed search [1] n/a

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.[1][2]

Clinical significance[edit]

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.[1]


  1. ^ a b Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805. 
  2. ^ Deloukas P, Earthrowl ME, Grafham DV et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 

Further reading[edit]

  • Brandenberger R, Wei H, Zhang S et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.