ASAHL
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| N-acylethanolamine acid amidase | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NAAA; ASAHL; PLT | ||||||||||||
| External IDs | OMIM: 607469 MGI: 1914361 HomoloGene: 8686 GeneCards: NAAA Gene | ||||||||||||
| EC number | 3.5.1.- | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 27163 | 67111 | |||||||||||
| Ensembl | ENSG00000138744 | ENSMUSG00000029413 | |||||||||||
| UniProt | Q02083 | Q9D7V9 | |||||||||||
| RefSeq (mRNA) | NM_001042402.1 | NM_001163687.1 | |||||||||||
| RefSeq (protein) | NP_001035861.1 | NP_001157159.1 | |||||||||||
| Location (UCSC) | Chr 4: 76.83 – 76.86 Mb |
Chr 5: 92.69 – 92.71 Mb |
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| PubMed search | [1] | [2] | |||||||||||
N-acylethanolamine-hydrolyzing acid amidase is an enzyme that in humans is encoded by the NAAA gene.[1][2][3]
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
[edit] References
- ^ Hong SB, Li CM, Rhee HJ, Park JH, He X, Levy B, Yoo OJ, Schuchman EH (Feb 2000). "Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein". Genomics 62 (2): 232–41. doi:10.1006/geno.1999.5953. PMID 10610717.
- ^ Goodchild NL, Wilkinson DA, Mager DL (Dec 1992). "A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta". Gene 121 (2): 287–94. doi:10.1016/0378-1119(92)90133-A. PMID 1446826.
- ^ a b "Entrez Gene: ASAHL N-acylsphingosine amidohydrolase (acid ceramidase)-like". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27163.
[edit] Further reading
- Schulze H, Schepers U, Sandhoff K (2008). "Overexpression and mass spectrometry analysis of mature human acid ceramidase.". Biol. Chem. 388 (12): 1333–43. doi:10.1515/BC.2007.152. PMID 18020949.
- Zhao LY, Tsuboi K, Okamoto Y, et al. (2008). "Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism.". Biochim. Biophys. Acta 1771 (11): 1397–405. doi:10.1016/j.bbalip.2007.10.002. PMID 17980170.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Tsuboi K, Sun YX, Okamoto Y, et al. (2005). "Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase.". J. Biol. Chem. 280 (12): 11082–92. doi:10.1074/jbc.M413473200. PMID 15655246.
- Huang Y, Tanimukai H, Liu F, et al. (2005). "Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain.". Eur. J. Neurosci. 20 (12): 3489–97. doi:10.1111/j.1460-9568.2004.03852.x. PMID 15610181.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
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