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Small nuclear ribonucleoprotein 200kDa (U5)
Protein ASCC3L1 PDB 2q0z.png
PDB rendering based on 2q0z.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SNRNP200 ; ASCC3L1; BRR2; HELIC2; RP33; U5-200KD
External IDs OMIM601664 MGI2444401 HomoloGene5859 GeneCards: SNRNP200 Gene
EC number
Species Human Mouse
Entrez 23020 320632
Ensembl ENSG00000144028 ENSMUSG00000003660
UniProt O75643 Q6P4T2
RefSeq (mRNA) NM_014014 NM_177214
RefSeq (protein) NP_054733 NP_796188
Location (UCSC) Chr 2:
96.94 – 96.97 Mb
Chr 2:
127.21 – 127.24 Mb
PubMed search [1] [2]

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.[1][2][3][4][5]


  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
  2. ^ Lauber J, Fabrizio P, Teigelkamp S, Lane WS, Hartmann E, Luhrmann R (Oct 1996). "The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases". EMBO J 15 (15): 4001–15. PMC 452120. PMID 8670905. 
  3. ^ Achsel T, Ahrens K, Brahms H, Teigelkamp S, Luhrmann R (Nov 1998). "The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein". Mol Cell Biol 18 (11): 6756–66. PMC 109259. PMID 9774689. 
  4. ^ Laggerbauer B, Achsel T, Luhrmann R (May 1998). "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro". Proc Natl Acad Sci U S A 95 (8): 4188–92. doi:10.1073/pnas.95.8.4188. PMC 22463. PMID 9539711. 
  5. ^ "Entrez Gene: ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1". 

Further reading[edit]