ATF5

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Activating transcription factor 5
Identifiers
Symbols ATF5 ; ATFX; HMFN0395
External IDs OMIM606398 MGI2141857 HomoloGene32142 GeneCards: ATF5 Gene
RNA expression pattern
PBB GE ATF5 204998 s at tn.png
PBB GE ATF5 204999 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22809 107503
Ensembl ENSG00000169136 ENSMUSG00000038539
UniProt Q9Y2D1 O70191
RefSeq (mRNA) NM_001193646 NM_030693
RefSeq (protein) NP_001180575 NP_109618
Location (UCSC) Chr 19:
50.43 – 50.44 Mb
Chr 7:
44.81 – 44.82 Mb
PubMed search [1] [2]

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.[1]

Function[edit]

First described by Nishizawa and Nagata,[2] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.[3][4]

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.

See also[edit]

Interactions[edit]

ATF5 has been shown to interact with DISC1[5] and TRIB3.[6]

References[edit]

  1. ^ "Entrez Gene: ATF5 activating transcription factor 5". 
  2. ^ Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. PMC 84326. PMID 10373550. 
  3. ^ Hai T, Hartman MG (July 2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene 273 (1): 1–11. doi:10.1016/S0378-1119(01)00551-0. PMID 11483355. 
  4. ^ Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M (September 2002). "Classification of human B-ZIP proteins based on dimerization properties". Mol. Cell. Biol. 22 (18): 6321–6335. doi:10.1128/MCB.22.18.6321-6335.2002. PMC 135624. PMID 12192032. 
  5. ^ Morris, Jill A; Kandpal Geeta; Ma Lei; Austin Christopher P (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. (England) 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. ISSN 0964-6906. PMID 12812986. 
  6. ^ Zhou, Ying; Li Lu; Liu Qiongming; Xing Guichun; Kuai Xuezhang; Sun Jing; Yin Xiushan; Wang Jian; Zhang Lingqiang; He Fuchu (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. (England) 20 (5): 942–948. doi:10.1016/j.cellsig.2008.01.010. ISSN 0898-6568. PMID 18276110. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.