ATOH1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Atonal homolog 1 (Drosophila)
Identifiers
Symbols ATOH1 ; ATH1; HATH1; MATH-1; bHLHa14
External IDs OMIM601461 MGI104654 HomoloGene31297 GeneCards: ATOH1 Gene
RNA expression pattern
PBB GE ATOH1 221336 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 474 11921
Ensembl ENSG00000172238 ENSMUSG00000073043
UniProt Q92858 P48985
RefSeq (mRNA) NM_005172 NM_007500
RefSeq (protein) NP_005163 NP_031526
Location (UCSC) Chr 4:
94.75 – 94.75 Mb
Chr 6:
64.73 – 64.73 Mb
PubMed search [1] [2]

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.[1][2]

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.[2] ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal. ATOH1 is considered part of the Notch signaling pathway.

In 2009, ATOH1 was identified as a "cancer switch-off" gene. [3]

References[edit]

  1. ^ Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (Jan 1997). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Hum Mol Genet 5 (9): 1207–16. doi:10.1093/hmg/5.9.1207. PMID 8872459. 
  2. ^ a b "Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.