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ATPase, Na+/K+ transporting, beta 1 polypeptide
Symbols ATP1B1 ; ATP1B
External IDs OMIM182330 MGI88108 HomoloGene37509 IUPHAR: 837 ChEMBL: 2379 GeneCards: ATP1B1 Gene
RNA expression pattern
PBB GE ATP1B1 201242 s at tn.png
PBB GE ATP1B1 201243 s at tn.png
More reference expression data
Species Human Mouse
Entrez 481 11931
Ensembl ENSG00000143153 ENSMUSG00000026576
UniProt P05026 P14094
RefSeq (mRNA) NM_001001787 NM_009721
RefSeq (protein) NP_001668 NP_033851
Location (UCSC) Chr 1:
169.07 – 169.1 Mb
Chr 1:
164.44 – 164.46 Mb
PubMed search [1] [2]

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.[1]

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]


Further reading[edit]