From Wikipedia, the free encyclopedia
Jump to: navigation, search
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Protein ATP5B PDB 1bmf.png
PDB rendering based on 1bmf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ATP5B ; ATPMB; ATPSB; HEL-S-271
External IDs OMIM102910 MGI107801 HomoloGene1273 IUPHAR: 797 GeneCards: ATP5B Gene
EC number
RNA expression pattern
PBB GE ATP5B 201322 at tn.png
PBB GE ATP5B gnf1h05947 s at tn.png
More reference expression data
Species Human Mouse
Entrez 506 11947
Ensembl ENSG00000110955 ENSMUSG00000025393
UniProt P06576 P56480
RefSeq (mRNA) NM_001686 NM_016774
RefSeq (protein) NP_001677 NP_058054
Location (UCSC) Chr 12:
57.03 – 57.04 Mb
Chr 10:
128.08 – 128.09 Mb
PubMed search [1] [2]

ATP synthase subunit beta, mitochondrial is an enzyme that in humans is encoded by the ATP5B gene.[1][2]


This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.[2]


  1. ^ Neckelmann N, Warner CK, Chung A, Kudoh J, Minoshima S, Fukuyama R et al. (Jan 1990). "The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression". Genomics 5 (4): 829–43. doi:10.1016/0888-7543(89)90125-0. PMID 2687158. 
  2. ^ a b "Entrez Gene: ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide". 

Further reading[edit]