ATP5F1

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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
Identifiers
Symbols ATP5F1 ; PIG47
External IDs OMIM603270 MGI1100495 HomoloGene1275 GeneCards: ATP5F1 Gene
RNA expression pattern
PBB GE ATP5F1 211755 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 515 11950
Ensembl ENSG00000116459 ENSMUSG00000000563
UniProt P24539 Q9CQQ7
RefSeq (mRNA) NM_001688 NM_009725
RefSeq (protein) NP_001679 NP_033855
Location (UCSC) Chr 1:
111.99 – 112.01 Mb
Chr 3:
105.94 – 105.96 Mb
PubMed search [1] [2]
ATP-synt_B
PDB 1l2p EBI.jpg
atp synthase b subunit dimerization domain
Identifiers
Symbol ATP-synt_B
Pfam PF00430
Pfam clan CL0255
InterPro IPR002146
SCOP 1b9u
SUPERFAMILY 1b9u

ATP synthase subunit b, mitochondrial is an enzyme that in humans is encoded by the ATP5F1 gene.[1][2]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel.[2]

The b subunits are part of the peripheral stalk that links the F1 and FO complexes together, and which acts as a stator to prevent certain subunits from rotating with the central rotary element. The peripheral stalk differs in subunit composition between mitochondrial, chloroplast and bacterial F-ATPases. In bacterial and chloroplast F-ATPases, the peripheral stalk is composed of one copy of the delta subunit (homologous to OSCP in mitochondria), and two copies of subunit b in bacteria, or one copy each of subunits b and b' in chloroplasts and photosynthetic bacteria.[3]

References[edit]

  1. ^ Higuti T, Tsurumi C, Osaka F, Kawamura Y, Tsujita H, Yoshihara Y, Tani I, Tanaka K, Ichihara A (Sep 1991). "Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria". Biochem Biophys Res Commun 178 (3): 1014–20. doi:10.1016/0006-291X(91)90993-H. PMID 1831354. 
  2. ^ a b "Entrez Gene: ATP5F1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1". 
  3. ^ Carbajo RJ, Kellas FA, Runswick MJ, Montgomery MG, Walker JE, Neuhaus D (August 2005). "Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit". J. Mol. Biol. 351 (4): 824–38. doi:10.1016/j.jmb.2005.06.012. PMID 16045926. 

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro IPR002146