ATP5G3

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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
Identifiers
Symbols ATP5G3 ; P3
External IDs OMIM602736 MGI2442035 HomoloGene1276 GeneCards: ATP5G3 Gene
RNA expression pattern
PBB GE ATP5G3 207507 s at tn.png
PBB GE ATP5G3 207508 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 518 228033
Ensembl ENSG00000154518 ENSMUSG00000018770
UniProt P48201 P56384
RefSeq (mRNA) NM_001002258 NM_175015
RefSeq (protein) NP_001002258 NP_778180
Location (UCSC) Chr 2:
176.04 – 176.05 Mb
Chr 2:
73.91 – 73.91 Mb
PubMed search [1] [2]

ATP synthase lipid-binding protein, mitochondrial is an enzyme that in humans is encoded by the ATP5G3 gene.[1][2]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.[2]

References[edit]

  1. ^ Yan WL, Lerner TJ, Haines JL, Gusella JF (May 1995). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763. 
  2. ^ a b "Entrez Gene: ATP5G3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)". 

Further reading[edit]