ATP5H

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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
Identifiers
Symbols ATP5H ; ATPQ
External IDs MGI1918929 HomoloGene130552 GeneCards: ATP5H Gene
EC number 3.6.1.14
RNA expression pattern
PBB GE ATP5H 210149 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10476 71679
Ensembl ENSG00000167863 n/a
UniProt O75947 n/a
RefSeq (mRNA) NM_001003785 NM_027862
RefSeq (protein) NP_001003785 NP_082138
Location (UCSC) Chr 17:
73.03 – 73.04 Mb
n/a
PubMed search [1] [2]
ATP synthase D chain, mitochondrial
Identifiers
Symbol ATP5H
Pfam PF05873

The human gene ATP5H encodes subunit d of the enzyme mitochondrial ATP synthase.[1][2]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F0 seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the F0 complex.

Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.[2]

References[edit]

  1. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. 
  2. ^ a b "Entrez Gene: ATP5H ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d". 

Further reading[edit]