ATP5J2

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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
Identifiers
Symbols ATP5J2 ; ATP5JL
External IDs MGI1927558 HomoloGene3594 GeneCards: ATP5J2 Gene
EC number 3.6.1.14
RNA expression pattern
PBB GE ATP5J2 202961 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9551 57423
Ensembl ENSG00000241468 ENSMUSG00000038690
UniProt P56134 P56135
RefSeq (mRNA) NM_001003713 NM_020582
RefSeq (protein) NP_001003713 NP_065607
Location (UCSC) Chr 7:
99.05 – 99.06 Mb
Chr 5:
145.18 – 145.19 Mb
PubMed search [1] [2]

The ATP5J2 gene [1][2] encodes the ATP synthase subunit f, mitochondrial enzyme in humans.

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the F0 complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes.[2]

References[edit]

  1. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160. 
  2. ^ a b "Entrez Gene: ATP5J2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2". 

Further reading[edit]