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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
Symbols ATP5S ; ATPW; FB; HSU79253
External IDs MGI1915305 HomoloGene12232 GeneCards: ATP5S Gene
EC number
PBB GE ATP5S 213995 at tn.png
Species Human Mouse
Entrez 27109 68055
Ensembl ENSG00000125375 ENSMUSG00000054894
UniProt Q99766 Q9CRA7
RefSeq (mRNA) NM_001003803 NM_026536
RefSeq (protein) NP_001003803 NP_080812
Location (UCSC) Chr 14:
50.78 – 50.8 Mb
Chr 12:
69.72 – 69.74 Mb
PubMed search [1] [2]

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.[1][2][3]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]


  1. ^ Belogrudov GI, Hatefi Y (Feb 2002). "Factor B and the mitochondrial ATP synthase complex". J Biol Chem 277 (8): 6097–103. doi:10.1074/jbc.M111256200. PMID 11744738. 
  2. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  3. ^ a b "Entrez Gene: ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)". 

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