ATPase, H+ transporting, lysosomal V0 subunit a1

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ATPase, H+ transporting, lysosomal V0 subunit a1
Identifiers
Symbols ATP6V0A1 ; ATP6N1; ATP6N1A; Stv1; VPP1; Vph1; a1
External IDs OMIM192130 MGI103286 HomoloGene3795 GeneCards: ATP6V0A1 Gene
EC number 3.6.3.14
RNA expression pattern
PBB GE ATP6V0A1 212383 at tn.png
PBB GE ATP6V0A1 205095 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 535 11975
Ensembl ENSG00000033627 ENSMUSG00000019302
UniProt Q93050 Q9Z1G4
RefSeq (mRNA) NM_001130020 NM_001243049
RefSeq (protein) NP_001123492 NP_001229978
Location (UCSC) Chr 17:
40.61 – 40.67 Mb
Chr 11:
101.01 – 101.06 Mb
PubMed search [1] [2]

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.[1][2]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. The occurrence of splice variants encoding different protein products has been reported, but the full-length natures of these transcripts have not been determined.[2]

References[edit]

  1. ^ Brody LC, Abel KJ, Castilla LH, Couch FJ, McKinley DR, Yin G, Ho PP, Merajver S, Chandrasekharappa SC, Xu J, et al. (Jul 1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics 25 (1): 238–47. doi:10.1016/0888-7543(95)80131-5. PMID 7774924. 
  2. ^ a b "Entrez Gene: ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1". 

Further reading[edit]