ATP6V0D1

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ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
Identifiers
Symbols ATP6V0D1 ; ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD
External IDs OMIM607028 MGI1201778 HomoloGene3444 GeneCards: ATP6V0D1 Gene
EC number 3.6.3.14
RNA expression pattern
PBB GE ATP6V0D1 212041 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9114 11972
Ensembl ENSG00000159720 ENSMUSG00000013160
UniProt P61421 P51863
RefSeq (mRNA) NM_004691 NM_013477
RefSeq (protein) NP_004682 NP_038505
Location (UCSC) Chr 16:
67.47 – 67.52 Mb
Chr 8:
105.52 – 105.57 Mb
PubMed search [1] [2]

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.[1][2]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.[2]

References[edit]

  1. ^ van Hille B, Vanek M, Richener H, Green JR, Bilbe G (Jan 1994). "Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase". Biochem Biophys Res Commun 197 (1): 15–21. doi:10.1006/bbrc.1993.2434. PMID 8250920. 
  2. ^ a b "Entrez Gene: ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1". 

Further reading[edit]