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ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
Symbols ATP6V0E1 ; ATP6H; ATP6V0E; M9.2; Vma21; Vma21p
External IDs OMIM603931 MGI1328318 HomoloGene2931 GeneCards: ATP6V0E1 Gene
EC number
RNA expression pattern
PBB GE ATP6V0E1 200096 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8992 11974
Ensembl ENSG00000113732 ENSMUSG00000015575
UniProt O15342 Q9CQD8
RefSeq (mRNA) NM_003945 NM_025272
RefSeq (protein) NP_003936 NP_079548
Location (UCSC) Chr 5:
172.41 – 172.46 Mb
Chr 17:
26.68 – 26.7 Mb
PubMed search [1] [2]

V-type proton ATPase subunit e 1 is an enzyme that in humans is encoded by the ATP6V0E1 gene.[1][2][3]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dogs, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3.[3]


  1. ^ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem 273 (18): 10939–10947. doi:10.1074/jbc.273.18.10939. PMID 9556572. 
  2. ^ Sambade M, Kane PM (Apr 2004). "The yeast vacuolar proton-translocating ATPase contains a subunit homologous to the Manduca sexta and bovine e subunits that is essential for function". J Biol Chem 279 (17): 17361–17365. doi:10.1074/jbc.M314104200. PMID 14970230. 
  3. ^ a b "Entrez Gene: ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1". 

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