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ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
Symbols ATP6V1D ; ATP6M; VATD; VMA8
External IDs OMIM609398 MGI1921084 HomoloGene5783 IUPHAR: 815 GeneCards: ATP6V1D Gene
EC number
Species Human Mouse
Entrez 51382 73834
Ensembl ENSG00000100554 ENSMUSG00000021114
UniProt Q9Y5K8 P57746
RefSeq (mRNA) NM_015994 NM_023721
RefSeq (protein) NP_057078 NP_076210
Location (UCSC) Chr 14:
67.29 – 67.36 Mb
Chr 12:
78.84 – 78.86 Mb
PubMed search [1] [2]

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.[1][2]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.[2]


  1. ^ Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu Rev Cell Dev Biol 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887. 
  2. ^ a b "Entrez Gene: ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D". 

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