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ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
Symbols ATP6V1G1 ; ATP6G; ATP6G1; ATP6GL; ATP6J; Vma10
External IDs OMIM607296 MGI1913540 HomoloGene31272 IUPHAR: 819 GeneCards: ATP6V1G1 Gene
EC number
RNA expression pattern
PBB GE ATP6V1G1 208737 at tn.png
More reference expression data
Species Human Mouse
Entrez 9550 66290
Ensembl ENSG00000136888 ENSMUSG00000039105
UniProt O75348 Q9CR51
RefSeq (mRNA) NM_004888 NM_024173
RefSeq (protein) NP_004879 NP_077135
Location (UCSC) Chr 9:
117.35 – 117.36 Mb
Chr 4:
63.54 – 63.55 Mb
PubMed search [1] [2]

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.[1][2]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized.[2]


  1. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160. 
  2. ^ a b "Entrez Gene: ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1". 

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