ATP6V1G1

ATP6V1G1
Identifiers
Aliases	ATP6V1G1, ATP6G, ATP6G1, ATP6GL, ATP6J, Vma10, ATPase H+ transporting V1 subunit G1
External IDs	OMIM: 607296 MGI: 1913540 HomoloGene: 31272 GeneCards: ATP6V1G1
Gene location (Human) Chr. Chromosome 9 (human) Band 9q32 Start 114,587,706 bp End 114,598,915 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B3 Start 63,463,009 bp End 63,468,987 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla pylorus cardia ganglionic eminence retinal pigment epithelium corpus epididymis anterior pituitary oral cavity superior surface of tongue monocyte Top expressed in yolk sac spermatocyte lip superior frontal gyrus morula spermatid proximal tubule thymus neural tube esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase binding ATPase activity P-type proton-exporting transporter activity protein binding ATPase-coupled transmembrane transporter activity Cellular component cytosol plasma membrane intracellular anatomical structure lysosomal membrane vacuolar proton-transporting V-type ATPase complex extracellular exosome Biological process insulin receptor signaling pathway transferrin transport proton transmembrane transport ion transport ion transmembrane transport regulation of macroautophagy phagosome acidification cellular iron ion homeostasis cellular response to increased oxygen levels transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9550 66290 Ensembl ENSG00000136888 ENSMUSG00000039105 UniProt O75348 Q9CR51 RefSeq (mRNA) NM_004888 NM_024173 RefSeq (protein) NP_004879 NP_004879.1 NP_077135 Location (UCSC) Chr 9: 114.59 – 114.6 Mb Chr 4: 63.46 – 63.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized.

External links

• Human ATP6V1G1 genome location and ATP6V1G1 gene details page in the UCSC Genome Browser.

Further reading

• Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". Biochem. J. 324 (Pt 3): 697–712. doi:10.1042/bj3240697. PMC 1218484. PMID 9210392.
• Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu. Rev. Cell Dev. Biol. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
• Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiol. Rev. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID 10221984. S2CID 1477911.
• Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases". J. Biol. Chem. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
• Kane PM (1999). "Introduction: V-ATPases 1992-1998". J. Bioenerg. Biomembr. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
• Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860. S2CID 23505139.
• Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
• Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
• Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263. S2CID 17519696.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Smith AN, Borthwick KJ, Karet FE (2003). "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis". Gene. 297 (1–2): 169–77. doi:10.1016/S0378-1119(02)00884-3. PMID 12384298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.