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ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
Symbols ATP6V1G3 ; ATP6G3; Vma10
External IDs MGI2450548 HomoloGene13630 IUPHAR: 821 GeneCards: ATP6V1G3 Gene
EC number
Species Human Mouse
Entrez 127124 338375
Ensembl ENSG00000151418 ENSMUSG00000026394
UniProt Q96LB4 Q8BMC1
RefSeq (mRNA) NM_133262 NM_177397
RefSeq (protein) NP_573569 NP_796371
Location (UCSC) Chr 1:
198.49 – 198.51 Mb
Chr 1:
138.27 – 138.29 Mb
PubMed search [1] [2]

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.[1][2]


This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887. 
  2. ^ a b "Entrez Gene: ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3". 

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