ATRN

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For the ATRN Extended SMTP command, see On-Demand Mail Relay.
Attractin
Identifiers
Symbols ATRN ; DPPT-L; MGCA
External IDs OMIM603130 MGI1341628 HomoloGene22542 GeneCards: ATRN Gene
RNA expression pattern
PBB GE ATRN 212517 at tn.png
PBB GE ATRN 211852 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8455 11990
Ensembl ENSG00000088812 ENSMUSG00000027312
UniProt O75882 Q9WU60
RefSeq (mRNA) NM_001207047 NM_009730
RefSeq (protein) NP_001193976 NP_033860
Location (UCSC) Chr 20:
3.45 – 3.63 Mb
Chr 2:
130.91 – 131.03 Mb
PubMed search [1] [2]

Attractin is a protein that in humans is encoded by the ATRN gene.[1][2][3]

Attractin is a Group XI C-type lectin.

Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.[3]

References[edit]

  1. ^ Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ, Schlossman SF (Oct 1998). "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions". Proc Natl Acad Sci U S A 95 (19): 11336–41. doi:10.1073/pnas.95.19.11336. PMC 21643. PMID 9736737. 
  2. ^ Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman SF (Apr 1996). "Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells". J Immunol 156 (5): 1714–21. PMID 8596018. 
  3. ^ a b "Entrez Gene: ATRN attractin". 

Further reading[edit]