The song was one of Coheed and Cambria's breakout singles. It features the characters Claudio and Al the Killer, and is part of the sci-fi saga that is present in all of the band's songs. In contrast to other songs on the album, "A Favor House Atlantic" has been described as a "fairly straightforward [slice] of emo".
There are two versions of the music video of the song. The first, directed by Christian Winters, revolves around the band in a bar, attempting to pick up women. Meanwhile, an alternate version of the band performs the song on the stage. This version could be considered an "80s" version of the band as they wear typical 80s rock style attire such as headbands and tight clothes.
The video's humor is very tongue-in-cheek featuring antics such as drummer Josh Eppard attempting to look up girls' dresses, bassist Michael Todd in a drunken stupor soliciting the services of a drag queen, and the band insulting itself.
The second version is an animated video, telling a story from the Amory Wars. Rather than being about Claudio and Al the Killer, however, it is about Coheed and Cambria as teenagers.