Diagram of an ectodomain shedding ADAM metalloprotease.
ADAM (A Disintegrin And Metalloproteinase) is a family of peptidase proteins. It is also known as the adamalysin family or MDC family(metalloproteinase-like, Disintegrin-like, cysteine rich). ADAMs are classified as sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM10 can cut off part of the HER2 receptor, activating it. Therapeutic ADAM inhibitors can potentiate anti-cancer therapy.
^Wolfsberg TG, Straight PD, Gerena RL, et al. (1995). "ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain". Dev. Biol.169 (1): 378–383. doi:10.1006/dbio.1995.1152. PMID7750654.
^Liu, P.C.; et al. (2006). "Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.". Cancer Biology and Therapy5 (6): 657–664. doi:10.4161/cbt.5.6.2708. PMID16627989.