Sir Aaron Klug, (born 11 August 1926) is a Lithuanian-born OM, FRS British [3 ] chemist and biophysicist, and winner of the 1982 Nobel Prize in Chemistry for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes. [4 ] [5 ] [6 ]
Biography [ edit ]
Klug was born in
Želva, Lithuania to Jewish parents Lazar, a cattleman, and Bella (née Silin) Klug with whom he moved to South Africa at the age of two. He later graduated with a degree in science at the [7 ] University of Witwatersrand and studied crystallography at the University of Cape Town before he was awarded an 1851 Research Fellowship from the Royal Commission for the Exhibition of 1851, which enabled him to move to England, completing his doctorate at [8 ] Trinity College, Cambridge in 1953.
He moved to
Birkbeck College in the University of London in late 1953, and started working with Rosalind Franklin in John Bernal's lab. This experience aroused a lifelong interest in the study of viruses, and during his time there he made discoveries in the structure of the [9 ] tobacco mosaic virus. In 1962 he moved to the newly built MRC Laboratory of Molecular Biology in Cambridge. Over the following decade Klug used methods from X-ray diffraction, microscopy and structural modelling to develop crystallographic electron microscopy in which a sequence of two-dimensional images of crystals taken from different angles are combined to produce three-dimensional images of the target. In 1962 Klug was offered a teaching Fellowship at Peterhouse Cambridge. He went on teaching after his Nobel Prize because he found the courses interesting and was later made an Honorary Fellow at the College. [10 ]
He was awarded the
Louisa Gross Horwitz Prize from Columbia University in 1981. Between 1986 and 1996 he was director of the Laboratory of Molecular Biology in Cambridge, and was knighted by Elizabeth II in 1988. He was elected President of the [3 ] Royal Society, and served from 1995–2000. He was appointed OM in 1995 – as is customary for Presidents of the Royal Society. He is also a member of the Board of Scientific Governors at The Scripps Research Institute.
In 2005 he was awarded South Africa's
Order of Mapungubwe (gold) for exceptional achievements in medical science. [11 ]
He is a member of the Advisory Council for the
Campaign for Science and Engineering. [12 ]
Though Klug had faced discrimination in South Africa, he remained religious and according to
Sydney Brenner, he's become more religious in his older age. [13 ]
See also [ edit ]
References [ edit ]
^ Aaron Klug at the Mathematics Genealogy Project
^ Shafrir, E. (1994). "Aaron Klug--a pioneer of crystallographic electron microscopy". Israel journal of medical sciences 30 (9): 734. PMID 8088991.
^ a b "Aaron Klug (1926–)". Jewish Virtual Library . Retrieved . 7 November 2009
^ Nobel Foundation (18 October 1982). "The Nobel Prize in Chemistry 1982" (Press release). The Royal Swedish Academy of Sciences . Retrieved . 13 September 2007
^ Wakabayashi, K. (1983). "Accomplishment of Dr. Aaron Klug, winner of Nobel prize in chemistry, 1982". Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 28 (2): 156–157. PMID 6342048.
^ Shampo, M. A.; Kyle, R. A. (1994). "Sir Aaron Klug--Nobel Prize winner for chemistry". Mayo Clinic proceedings. Mayo Clinic 69 (6): 556. doi: 10.1016/S0025-6196(12)62247-2. PMID 8189761.
^ "BBC – Desert Island Discs – Castaway : Sir Aaron Klug first broadcast Sunday 12 May 2002".
^ 1851 Royal Commission Archives
^ Amos, L.; Finch, J. T. (2004). "Aaron Klug and the revolution in biomolecular structure determination". Trends in Cell Biology 14 (3): 148–152. doi: 10.1016/j.tcb.2004.01.002. PMID 15003624.
^ "National Orders awards 27 September 2005". State of South Africa. 29 September 2005 . Retrieved . 13 September 2007
^ "Advisory Council of the Campaign for Science and Engineering" . Retrieved . 11 February 2011
^ Hargittai, Istva'n & Magdolna. 2006. Candid Science VI: More Conversations with Famous Scientists. Imperial College Press, p. 33
Further reading [ edit ]
Wikimedia Commons has media related to
. Aaron Klug
2002: Nelson Mandela, Allan Cormack, FW de Klerk, Basil Schonland, Peter Beighton, Hamilton Naki
2004: Sydney Brenner, Tshilidzi Marwala, Batmanathan Dayanand Reddy
2005: John Maxwell Coetzee, Aaron Klug, Tyeid Nunes Nabarro, Tebello Nyokong, Himladevi Soodyall
2006: Selig Percy Amoils, George Ellis, Lionel Opie, Patricia Berjak
2007: Claire Penn, Sibusiso Sibisi, Valerie Mizrahi
2008: Doris Lessing, Wieland Gevers, Phuti Ngoepe, Tim Noakes, Pragasen Pillay
2009: Bongani Mayosi
2010: Johann Lutjeharms, Monique Zaahl, Douglas Butterworth
2011: Pieter Steyn
2012: Oliver Reginald Tambo
2014: Malegapuru Makgoba, Glenda Gray, George Ekama, Bernie Fanaroff, Quarraisha Abdool Karim