The river rises from Miscoe Lake on the border of Wrentham, Massachusetts and Cumberland, Rhode Island, then flows south through Cumberland, Rhode Island where it provides water to numerous ponds, including Diamond Hill Reservoir, Arnold Mills Reservoir and Rawson Pond. It then flows back into Massachusetts and flows south through North Attleborough, past the village of Adamsdale. From there, the river flows back into Rhode Island and continues through Cumberland, providing water to Robin Hollow and Happy Hollow Ponds before flowing into the Blackstone River at the village of Valley Falls.
Below is a list of all crossings over Abbott Run. The list starts at the headwaters and heads downstream.
- West Street (MA 121)
- North Attleborough
- Hunts Bridge Road
- Cushman Road
- Mendon Road
- Dexter Street (RI 123)
- Mill Street
Burnt Swamp Brook and the Millers River are the only two named tributaries of Abbott Run, though it has many unnamed streams that also feed it.
- Maps from the United States Geological Survey