Abetimus

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Abetimus
Clinical data
Legal status ?
Identifiers
CAS number 169147-32-4 YesY
ATC code L04AA22
Chemical data
Formula ?
 YesY (what is this?)  (verify)

Abetimus is an immunosuppressant.[1] It is a synthetic biological called a tolerogen. It is made of four double-stranded oligodeoxyribonucleotides that are attached to a carrier platform and are designed to block specific B-cell anti double stranded DNA antibodies.[2] It may also complex anti dsDNA antibodies together, therefore disabling them. This way Abetimus is supposed to help treat Systemic Lupus Erythematosus and specifically nephritis.

References[edit]

  1. ^ (not listed) (2003). "Abetimus: Abetimus sodium, LJP 394". BioDrugs (Adis) 17 (3): 212–215. doi:10.2165/00063030-200317030-00009. ISSN 1173-8804. PMID 12749759. 
  2. ^ Wallace, Daniel J. (January 2001), "Clinical and pharmacological experience with LJP-394", Expert Opinion on Investigational Drugs (Informa) 10 (1): 111–117, doi:10.1517/13543784.10.1.111, ISSN 1354-3784, PMID 11116284, retrieved 2 April 2011