Abetimus
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| Clinical data | |
|---|---|
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 169147-32-4  |
| ATC code | L04AA22 |
| Chemical data | |
| Formula | ? |
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Abetimus is an immunosuppressant.[1] It is a synthetic biological called a tolerogen. It is made of four double-stranded oligodeoxyribonucleotides that are attached to a carrier platform and are designed to block specific B-cell anti double stranded DNA antibodies.[2] It may also complex anti dsDNA antibodies together, therefore disabling them. This way Abetimus is supposed to help treat Systemic Lupus Erythematosus and specifically nephritis.
[edit] References
- ^ (not listed) (2003). "Abetimus: Abetimus sodium, LJP 394". BioDrugs (Adis) 17 (3): 212–215. doi:10.2165/00063030-200317030-00009. ISSN 1173-8804. PMID 12749759.
- ^ Wallace, Daniel J. (January 2001), "Clinical and pharmacological experience with LJP-394", Expert Opinion on Investigational Drugs (Informa) 10 (1): 111–117, doi:10.1517/13543784.10.1.111, ISSN 1354-3784, PMID 11116284, http://informahealthcare.com/doi/abs/10.1517/13543784.10.1.111%20, retrieved 2 April 2011
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