Abraham Wikler (1910–1981) was an American psychiatrist and neurologist who made important discoveries in drug addiction. He was one of the first to promote a view of addiction as conditioned behavior, and made the first observations of conditioned response in drug withdrawal symptoms. His research on conditioning and relapse played a pioneering role in the neuroscientific study of addiction.
Wikler was born and grew up on the Lower East Side of New York City, the son of a Jewish butcher who had immigrated from the Probuzhna shtetl in Ukraine. He earned an M.D. from the Long Island College of Medicine in 1935. He joined the Lexington Narcotic Hospital, a prison farm run by the United States Public Health Service for drug addicts in Lexington, Kentucky, as an intern in 1940. There, he ran the narcotic-withdrawal ward and worked to quantify effects of opiates on addicts. He became interested in the neurophysiological basis for addiction, and the physiological changes caused by addiction, after successfully diagnosing a patient who had previously been thought to be grieving as having suffered physical brain damage. After the internship, he took a one year fellowship at Yale University and Northwestern University, where he studied the work of Ivan Pavlov on conditioning. He then returned to Lexington as associate director and chief of the section on experimental neuropsychiatry, one of three permanent staff researchers at the facility. In his work there, he observed both classical conditioning and operant conditioning in humans and in studies with rodents; from these observations, he hypothesized that conditioning led addicts to relapse long after the physical symptoms of their addiction had faded, and that the "hustling" behavior of addicts seeking their next fix was a symptom of conditioning.
Wikler retired from the USPHS in 1963 and joined the faculty of the University of Kentucky In 1967, the alumni association of the SUNY Downstate Medical Center (to which the Long Island College of Medicine had been renamed) gave him their Alumni Achievement Medallion for Distinguished Service to American Medicine. In 1976, he won the Nathan B. Eddy Award of the College on Problems of Drug Dependence. He had four children; the oldest, Marjorie Senechal, became a mathematician and historian of science at Smith College. He died on March 7, 1981, in Lexington.
- Kosten, Thomas R. (1998), Images in Psychiatry: Abraham Wikler, M.D., 1910–1981, The American Journal of Psychiatry 155 (8): 1109.
- Jaffe, Jerome H. (December 1981), Abraham Wikler: A scholar—sui generis, British Journal of Addiction 76 (4): 431–432, doi:10.1111/j.1360-0443.1981.tb03243.x.
- Ludwig, Arnold M. (1989), Understanding the Alcoholic's Mind: The Nature of Craving and How to Control It, Oxford University Press, pp. 43–44, ISBN 9780195059182.
- Campbell, Nancy Dianne (2007), Discovering Addiction: The Science and Politics of Substance Abuse Research, University of Michigan Press, ISBN 9780472116102. Page 203: "Neuroscience entered substance abuse research not as a revolution but as a legitimizing force deeply interconnected with behavioral antecedents and with Abraham Wikler's work on conditioning and the role of cues in triggering relapse."
- Senechal, Marjorie (2003), "Narco Brat", in Patey, D., Of Human Bondage, Smith College Studies in History 52, Smith College.
- Campbell (2007), "A disease sui generis: The conceptual contributions of Abraham Wikler", pp. 75ff.
- Marino, A. W. Martin, Jr. (December 1967), The President's Page, SUNY Downstate Medical Center Alumni Bulletin, XXIII (3): 5.
- Campbell (2007), p. 56.
- Campbell (2007), p. xvii.
- Award winners, College on Problems of Drug Dependence, retrieved 2013-07-16.
- Brunner, Regina Baron (1998), "Marjorie Wikler Senechal", in Morrow, Charlene; Perl, Teri, Notable Women in Mathematics: A Biographical Dictionary, Greenwood Press, pp. 225–229.
- McIntire, Timothy R. (2008), A Retrospective Survey of the Career of Abraham Wikler: Implications for the Understanding and Treatment of Drug Addiction in America Today, Boston University.