|Born||November 11, 1917|
|Died||May 27, 2009|
|Fields||Schizophrenia, Nutrition, Alcoholism|
|Known for||Promotion of megavitamin therapy as a treatment for schizophrenia and for alcoholism|
Abram Hoffer (November 11, 1917 – May 27, 2009) was a Canadian biochemist, physician and psychiatrist who developed a theory that nutrition and vitamins may be effective treatments for schizophrenia. It includes the use of large doses of vitamins and is commonly called megavitamin therapy in general. Hoffer is also known for his "adrenochrome hypothesis" of schizoaffective disorders and protocols for remediation based on natural compounds such as vitamins, minerals and specific fats. Hoffer was also involved in the discovery that high dose niacin can be used to treat high cholesterol and other dyslipidemias.
Hoffer was born in southern Saskatchewan, Canada, in 1917, the last of four children and the son of Israel Hoffer. Originally interested in agriculture, Hoffer earned both a Bachelor of Science and a Masters degree in agricultural chemistry from University of Saskatchewan in Saskatoon. He then took up a scholarship for a year of post-graduate work with the University of Minnesota, followed by work developing assays for niacin levels at a wheat products laboratory in Winnipeg. Hoffer earned a PhD in biochemistry in 1944, part of which involved the study of vitamins (particularly B vitamins and their effect on the body) and with an interest in nutrition went on to study medicine at the University of Manitoba in 1945. After two years of clinical work at the University of Toronto, Hoffer earned his MD in 1949. Though originally intending to be a general practitioner, during his degree Hoffer developed an interest in psychiatry. He married Rose Miller in 1942, and his son Bill Hoffer was born in 1944 followed by two more children, John and Miriam, in 1947 and 1949.
Hoffer was hired by the Saskatchewan Department of Public Health in 1950 to establish a provincial research program in psychiatry, and joined the Regina Psychiatric Services Branch, Department of Public Health in 1951. He remained the Director of Psychiatric Research until entering private practice in 1967. Critical of psychiatry for its emphasis on psychosomatic psychoanalysis and for what he considered a lack of adequate definition and measurement, Hoffer felt that biochemistry and human physiology may be used instead. He hypothesised that schizophrenics may lack the ability to remove the hallucinogenic catecholamine metabolite adrenochrome from their brains. Hoffer thought vitamin C could be used to reduce adrenochrome to adrenaline and niacin could be used as a methyl acceptor to prevent the conversion of noradrenaline into adrenaline. Hoffer called his theory the "adrenochrome hypothesis".
In 1967, Hoffer resigned some of his academic and administrative positions, entered into private psychiatric practice in Saskatoon, Saskatchewan and created the Journal of Schizophrenia (renamed the Journal of Orthomolecular Medicine in 1986). Hoffer used the journal to publish articles on what he called "nutritional psychiatry", later orthomolecular psychiatry, claiming his ideas were consistently rejected by mainstream journals because they were unacceptable to the medical establishment. In 1976, Hoffer relocated to Victoria, British Columbia and continued with his private psychiatric practice until his retirement in 2005. In 1994 Hoffer founded the International Society for Orthomolecular Medicine, holding its inaugural in Vancouver in April of the same year. Hoffer continued to provide nutritional consultations and served as editor of the Journal of Orthomolecular Medicine. He was also President of the Orthomolecular Vitamin Information Centre in Victoria, BC.
Hoffer died May 27, 2009 in Victoria, British Columbia, Canada.
Working in Saskatchewan with Humphry Osmond (who coined the term "psychedelic"), Hoffer and other scientists sought to find medicinal uses for hallucinogenic drugs. Part of the research involved Hoffer, Osmond and their wives consuming LSD in an effort to become better acquainted with, and better understand its effects, later joined by other experimenters and their wives. Their work began attracting the notoriety within professional, provincial and federal and political circles, and they were courted by the emerging movement to restrict peyote as well as Native American groups that used the substance in religious ceremonies. Hoffer, Osmond and others treated alcoholics with LSD. Canadian scientists reported a fifty percent success rate in one study, although Hoffer speculated that it was more likely the psychedelic experience of LSD, rather than simulated delirium tremens, that convinced the alcoholics to stop drinking.
While working at the Regina General Hospital in the 1950s, Hoffer and James Stephen examined the effects of large doses of niacin on various diseases, including schizophrenia; Hoffer theorized that adrenalin, when oxidized to adrenochrome was an endogenous neurotoxin that could cause schizophrenia. At the same time, another Canadian working in Saskatoon, pathologist Rudolf Altschul, was exploring the use of high doses of niacin to lower cholesterol in rabbits and patients with degenerative vascular disease. The three combined their work, and in 1955 produced a paper entitled "Influence of nicotinic acid on serum cholesterol in man." The paper summarized their research showing high-dose niacin significantly lowered cholesterol in both high cholesterol patients as well as low cholesterol control subjects. The results were replicated by researchers at the Mayo Clinic and in Germany the following year. High dose niacin has since become a treatment option for individuals with high blood cholesterol and related blood lipid abnormalities.
At such high doses niacin acts like a drug rather than a vitamin and may have side effects of intense flushing of the face and torso and, rarely, liver toxicity. Hoffer continued to promote niacin as a treatment for schizophrenia, though this approach was not accepted by mainstream medicine. Subsequent research suggested that Hoffer's adrenochrome theory had merit as people with schizophrenia have defects in the genes that produce glutathione S-transferase, which eliminates the byproducts of catecholamines from the brain. Though Hoffer and Osmond reported nicotinic acid could help with the treatment of schizophrenia, these results could not be replicated by others. Despite the apparent face validity of Hoffer's "transmethylation hypothesis" (in which it was thought that the production of catecholamines could sometimes go awry and produce a hallucinogenic neurotoxin), it was ultimately rejected for two reasons: the alleged neurotoxins could never been identified and the cause of schizophrenia became attributed to dysfunctions in neurotransmitters.
Hoffer's claims regarding schizophrenia and his theories of orthomolecular medicine have been criticized. In 1973, the American Psychiatric Association reported methodological flaws in Hoffer's work on niacin as a schizophrenia treatment and referred to follow-up studies that did not confirm any benefits of the treatment, prompting at least two responses.   Multiple additional studies in the United States, Canada, and Australia similarly failed to find benefits of megavitamin therapy to treat schizophrenia. The term "orthomolecular medicine" was labeled a misnomer as early as 1973. Psychiatrist and critic of psychiatry Thomas Szasz, who wrote The Myth of Mental Illness, called Hoffer's ideas about schizoprhenia "pure quackery" and his claims "arrogant" for attributing the condition to a nutrient deficiency as well as their support for Schizophrenics International, a group that attempts to deal with schizophrenia similar to alcoholism in Alcoholics Anonymous.
In a 2006 interview, Hoffer stated that while he felt that current mainstream psychiatric care was "terrible", his theories and treatments were starting to become more accepted. "We’re at a transition point. If I live another four or five years, I’ll see it."
- Hoffer Abram, Osmond Humphry (1960). Chemical Basis of Clinical Psychiatry. Springfield, Illinois: Thomas. OCLC 631787.
- Hoffer Abram (1962). Niacin therapy in psychiatry (American lecture series). Springfield, Illinois: Thomas. OCLC 1629909.
- Hoffer Abram (1992 (1966, 1978)). How to Live With Schizophrenia (2nd ed., revised ed.). Citadel Press. ISBN 0-8065-1382-9.
- Hoffer Abram (1966). New Hope for Alcoholics. University Books.
- Hoffer Abram, Osmond, H. and Weckowicz, T.E (1967). The Hallucinogens. Academic Press. ISBN 0-12-351850-4.
- Hoffer Abram; Osmond Humphry; Kelm H (1975). Hoffer-Osmond Diagnostic Test. Tuscaloosa, Alabama: Behavior Science Press.
- Hoffer A; Pauling L (2004). Healing Cancer: Complementary Vitamin & Drug Treatments. CCNM Press. ISBN 1-897025-11-4.
- Hoffer A; Saul A (2008). Orthomolecular Medicine For Everyone. Basic Health Publications, Inc. ISBN 1-59120-226-4.
- "ACS : Orthomolecular Medicine". American Cancer Society. 2007-06-19. Archived from the original on 29 March 2008. Retrieved 2008-04-04.
- Aaronson S et al. (2003). "Cancer medicine". Cancer medicine 6 (Frei, Emil; Kufe, Donald W.; Holland, James F., eds). Hamilton, Ont: BC Decker. p. 76. ISBN 1-55009-213-8.
- Nutrition Committee, Canadian Paediatric Society (1 January 1990). "Megavitamin and megamineral therapy in childhood. Nutrition Committee, Canadian Paediatric Society". CMAJ 143 (10): 1009–1013. PMC 1452516. PMID 1699646.
- Hoffer, A (Q1 1990). "The Adrenochrome Hypothesis and Psychiatry". Retrieved 2011-07-25.
- Altschul R; Hoffer A; Stephen JD. (1955). "Influence of nicotinic acid on serum cholesterol in man". Arch Biochem Biophys 54 (2): 558–559. doi:10.1016/0003-9861(55)90070-9. PMID 14350806.
- Dyck, 2008, p. 26.
- Hoffer, A. "Abram Hoffer’s CV and writings". Weeks Clinic for Corrective Medicine and Psychiatry. Retrieved 2010-05-19.
- Wipond R (2006-08-11). "An interview with Dr. Abram Hoffer". Focus. Retrieved 2010-05-19.
- Hoffer, A (2003-01-01). "Vitamins and Minerals Help Fight Off Diseases of The Mind and The Body". Life Extension. Life Extension Foundation. Retrieved 2010-05-19.
- Hoffer, A. "The History of the Journal of Orthomolecular Medicine". Archived from the original on 20 May 2011. Retrieved 18 June 2011.
- "International Society for Orthomolecular Medicine History". International Society for Orthomolecular Medicine. Retrieved 2012-05-16.
- "Self published". Orthomolecular Vitamin Information Centre.
- "Controversial Victoria psychiatrist Abram Hoffer dies at age 92". Times Colonist. 2009-05-28. Archived from the original on 2009-06-12. Retrieved 2009-05-29.
- Eisner, B (2004-02-11). "Humphrey Osmond Inventor of the Word "Psychedelic" Dies". Retrieved 2010-05-19.
- Dyck, 2008, p. 37.
- Dyck, 2008, p. 84-5.
- Hoffer, A (1970). "Treatment of alcoholism with psychedelic therapy". In Aaronson BS; Osmond H. Psychedelics, The Uses and Implications of Psychedelic Drugs. Anchor Books.
- Li, Jie Jack (2009). Triumph of the heart the story of statins. Oxford [Oxfordshire]: Oxford University Press. pp. 29–30. ISBN 0-19-532357-2.
- Scott D Mendelson (2008). Metabolic syndrome and psychiatric illness: interactions, pathophysiology, assessment and treatment. Amsterdam: Elsevier. pp. 164. ISBN 0-12-374240-4.
- Müller, CP; Jacobs B (eds.) (2009). Handbook of the Behavioral Neurobiology of Serotonin. Academic Press. pp. 587. ISBN 0-12-374634-5.
- Barrett, Stephen (2000-07-12). "Orthomolecular Therapy". Quackwatch.
- Lipton M, et al. (1973). Task Force Report on Megavitamin and Orthomolecular Therapy in Psychiatry. American Psychiatric Association.
- Hoffer A, Osmond H (1976). Megavitamin Therapy, In Reply To The American Psychiatric Association Task Force Report on Megavitamin and Orthomolecular Therapy in Psychiatry. Canadian Schizophrenia Foundation.
- Kelm H (1978). A Reply To The American Psychiatric Association Task Force Report on Megavitamin and Orthomolecular Therapy in Psychiatry: The HOD Test (4). Orthomolecular Psychiatry. pp. 258–262. Unknown parameter
- Wittenborn JR; Weber ESP; Brown M (1973). "Niacin in the Long-Term Treatment of Schizophrenia". Archives of General Psychiatry 28 (3): 308–15. doi:10.1001/archpsyc.1973.01750330010002. PMID 4569673.
- "Nicotinic Acid in the Treatment of Schizophrenia: A Summary Report". Schizophrenia Bulletin 1 (3): 5–7. 1970. doi:10.1093/schbul/1.3.5.
- Vaughan K; McConaghy N (1999). "Megavitamin and dietary treatment in schizophrenia: a randomised, controlled trial". Australian and New Zealand Journal of Psychiatry 33 (1): 84–8. doi:10.1046/j.1440-1614.1999.00527.x. PMID 10197889.
- Szasz, T (1988). Schizophrenia: the sacred symbol of psychiatry. Syracuse University Press. pp. 112–4. ISBN 0-8156-0224-3.
- Dyck, E (2008). Psychedelic psychiatry: LSD from clinic to campus. Johns Hopkins University Press. ISBN 0-8018-8994-4.