Abrin

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For the village in Iran, see Abrin, Iran.
Jequirity, the source plant of abrin

Abrin is a highly toxic toxalbumin found in the seeds of the rosary pea (jequirity pea). It has a median toxic dose of 0.7 micrograms per kilogram of body mass when given to mice intravenously.[1] The median toxic dose for humans ranges from 10 to 1000 micrograms per kilogram when ingested and is 3.3 micrograms per kilogram when inhaled.[2]

Abrin, like ricin, is a ribosome inhibiting protein and the toxin can also be found in the seeds of the castor oil plant.[3] It is classed as a "Select Agent" under U.S. law.

Physical properties[edit]

Abrin is a water-soluble[citation needed] lectin. Powdered abrin is yellowish-white in colour[citation needed]. Abrin is a stable substance[citation needed].

Use[edit]

Abrin is not known to have been weaponised.[4] Abrin naturally occurs in the seeds of the rosary pea, a plant common to tropical regions that is occasionally employed as an herbal remedy for certain conditions.[5] While the outer shell of the seed protects its contents from the stomachs of most mammals[citation needed], they are occasionally punctured to make beaded jewelry. This can lead to poisoning if one is swallowed, or if a piece of such jewelry is worn against damaged skin.[6][7] Abrin has been shown to act as an immunoadjuvant in the treatment of cancer in mice.[8]

Toxicity[edit]

Abrin works by penetrating the cells of the body and inhibiting cell protein synthesis. By attaching to a carbohydrate chain on the cell surface, the abrin molecule anchors itself to the cell, is subsequently engulfed and enters the inner parts of the cell where it reacts with a ribosomal subunit and interferes with the normal protein synthesis process of the cell. Without these proteins, cells cannot survive. This is harmful to the human body and will be fatal. The severity of the effects of abrin poisoning vary on the means of exposure to the substance (whether inhaled, ingested, or injected).

Signs and symptoms of abrin exposure[edit]

The major symptoms of abrin poisoning depend on the route of exposure and the dose received, though many organs may be affected in severe cases. Initial symptoms of abrin poisoning by inhalation may occur within 8 hours of exposure. Following ingestion of abrin, initial symptoms may occur in less than 6 hours but usually are delayed for 1 to 3 days.

Inhalation[edit]

Within a few hours of inhaling a small amount of abrin, the likely symptoms would be respiratory distress, fever, cough, nausea, and tightness in the chest. Heavy sweating may follow as well as pulmonary edema. This would make breathing even more difficult, and the skin might turn blue. Excess fluid in the lungs would be diagnosed by x-ray or by listening to the chest with a stethoscope. Finally, low blood pressure and respiratory failure may occur, leading to death.

Ingestion[edit]

If someone swallows a small amount of abrin, they will develop vomiting and diarrhea that may become bloody. Severe dehydration may be the result, followed by low blood pressure. Other signs or symptoms may include hallucinations, seizures, and blood in the urine. Within several days, the person’s liver, spleen, and kidneys might stop working, and the person will die.

Absorption[edit]

Abrin in the powder or mist form can cause redness and pain of the skin and the eyes. Death from abrin poisoning could take place within 36 to 72 hours of exposure, depending on the route of exposure (inhalation, ingestion, or injection) and the dose received. If death has not occurred in 3 to 8 days, the victim usually recovers.

Treatment[edit]

Because no antidote exists for abrin, the most important factor is avoiding abrin exposure in the first place. If exposure cannot be avoided, the most important factor is then getting the abrin off or out of the body as quickly as possible. Abrin poisoning is treated by giving victims supportive medical care to minimize the effects of the poisoning. The types of supportive medical care would depend on several factors, such as the route by which victims were poisoned (that is, whether poisoning was by inhalation, ingestion, or skin or eye exposure). Care could include such measures as helping victims breathe, giving them intravenous fluids, giving them medications to treat conditions such as seizure and low blood pressure, flushing their stomachs with activated charcoal (if the abrin has been very recently ingested), or washing out their eyes with water if their eyes are irritated.

See also[edit]

References[edit]

  1. ^ Gill DM (1982). "Bacterial toxins: a table of lethal amounts" (pdf). Microbiological Reviews 46 (1): 86–94. PMC 373212. PMID 6806598. 
  2. ^ http://jat.oxfordjournals.org/content/33/2/77.full.pdf
  3. ^ Dickers KJ, Bradberry SM, Rice P, Griffiths GD, Vale JA (2003). "Abrin poisoning". Toxicological Reviews 22 (3): 137–142. doi:10.2165/00139709-200322030-00002. PMID 15181663. 
  4. ^ "Facts About Abrin". Centers for Disease Control and Prevention. 
  5. ^ http://www.iloveindia.com/indian-herbs/abrus-precatorius.html
  6. ^ "Toxic bracelet ruined my life". Daily Mail. 18 April 2012. 
  7. ^ http://www.cdc.gov/niosh/ershdb/EmergencyResponseCard_29750000.html
  8. ^ Shionoya, H; Arai, H; Koyanagi, N; Ohtake, S; Kobayashi, H; Kodama, T; Kato, H; Tung, T. C.; Lin, J. Y. (1982). "Induction of antitumor immunity by tumor cells treated with abrin". Cancer research 42 (7): 2872–6. PMID 7083176.  edit

External links[edit]