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Chemical structure of acacetin
CAS number 480-44-4 N
PubChem 5280442
ChemSpider 4444099 YesY
ChEBI CHEBI:15335 YesY
Jmol-3D images Image 1
Image 2
Molecular formula C16H12O5
Molar mass 284.26 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Acacetin is an O-methylated flavone found in Robinia pseudoacacia (black locust), Turnera diffusa (damiana),[1] Betula pendula (silver birch),[2] and in the fern Asplenium normale.[3]

The enzyme apigenin 4'-O-methyltransferase uses S-adenosyl methionine and 5,7,4'-trihydroxyflavone (apigenin) to produce S-adenosylhomocysteine and 4'-methoxy-5,7-dihydroxyflavone (acacetin).


  1. ^ Zhao, J; Dasmahapatra, AK; Khan, SI; Khan, IA (December 2008). "Anti-aromatase activity of the constituents from damiana (Turnera diffusa)". Journal of Ethnopharmacology 120 (3): 387–393. doi:10.1016/j.jep.2008.09.016. PMID 18948180. 
  2. ^ Valkama, E; Salminen, J-P; Koricheva, J; Pihlaja, K. "Changes in Leaf Trichomes and Epicuticular Flavonoids during Leaf Development in Three Birch Taxa". Annals of Botany 94: 233–242. doi:10.1093/aob/mch131. 
  3. ^ UmiKalsom, Yusuf; Harborne, Jeffrey B. (1991). "Flavonoid distribution in asplenioid ferns". Pertanika 14 (3): 297–300.