Permethrin can be applied as a spray. The effects are not limited to mites: lice, cockroaches, fleas, mosquitos, and other insects will be affected. Permethrin, however, is not known to seriously harm most mammals or birds, as it has a low mammalian toxicity and is poorly absorbed by skin. Although Permethrin is toxic and potentially fatal to cats.
Ivermectin can be prescribed by a medical doctor to rid humans of mite and lice infestations, and agricultural formulations are available for infested birds and rodents.
Diatomaceous earth will also kill mites by disrupting their cuticles, which dries out the mites.
Dicofol, a compound structurally related to the insecticide DDT, is a miticide that is effective against the red spider mite Tetranychus urticae.
Lime sulfur is effective against sarcoptic mange. It is made by mixing hydrated lime, sulfur, and water, and boiling for about 1 hour. Hydrated lime can bond with about 1.7 its weight of sulfur. (Quicklime can bond with as much as 2.2 times its weight of sulfur). The strongest concentrate is diluted 1:32 before saturating the skin (avoiding the eyes), applied at six-day intervals.
Nonpesticide miticides act by causing desiccation, but are not a diatomaceous earth (which contain crystalline silica, potentially dangerous by inhalation), but made from a patented mix of food-grade components, one to breach the cuticle and one to ensure rapid, reliable desiccation. They can be dusted as powder or sprayed in aqueous solution.
Acaricides are also being used in attempts to stop Rhinoceros poaching. Holes are drilled into the horn of a sedated rhino and acaricide is pumped in and pressurized. Should the horn be consumed by humans as in Traditional Chinese Medicine, it is expected to cause nausea, stomach-ache and diarrhea, or convulsions, depending on the quantity, but not fatalities. Signs posted at wildlife refuges that the rhinos therein have been treated are thus expected to deter poaching. The original idea grew out of research into using the horn as a reservoir for one-time tick treatments; the acaricide is selected to be safe for the rhino, oxpeckers, vultures, and other animals in the preserve's ecosystem.