Acatalasia (also called acatalasemia, or Takahara's disease[1]:809) is an autosomal recessive peroxisomal disorder caused by a complete lack of catalase.
[edit] Presentation
The disorder is relatively benign, although it causes an increased incidence of periodontal infections, and can under rare circumstances lead to gangrene.[citation needed]
[edit] History
In 1948 , Dr.Shigeo Takahara (1908–1994), a Japanese otolaryngologist first reported this new disease.[2] He had examined a patient with an oral ulcer. He had spread hydrogen peroxide on the diseased part, but oxygen was not generated due to the lack of catalase.
[edit] See also
[edit] References
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Takahara, S.; Miyamoto, H. Three cases of progressive oral gangrene due to lack of catalase in the blood. Nippon Jibi-Inkoka Gakkai Kaiho 51: 163 only, 1948.
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| Peroxisome biogenesis disorder |
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| Enzyme-related |
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| Transporter-related |
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| Lysosomal |
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B structural (perx, skel, cili, mito, nucl, sclr) · DNA/RNA/protein synthesis (drep, trfc, tscr, tltn) · membrane (icha, slcr, atpa, abct, othr) · transduction (iter, csrc, itra), trfk
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