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Acetoacetyl coenzyme A.svg
CAS number 1420-36-6 N
PubChem 74
ChemSpider 83198 YesY
MeSH acetoacetyl+CoA
ChEBI CHEBI:15345 YesY
Jmol-3D images Image 1
Molecular formula C25H40N7O18P3S
Molar mass 851.609 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Acetoacetyl CoA is the precursor of HMG-CoA in the Mevalonate pathway, which is essential for cholesterol synthesis. It also takes a similar role in the ketone bodies synthesis pathway of the liver. In the ketone bodies digestion pathway (in the tissue), it is no longer associated with having HMG-CoA as a product or as a reactant.

It is created from acetyl-CoA by thiolase, and it is acted upon by HMG-CoA synthase to form HMG-CoA. During the metabolism of leucine, this last reaction is reversed.

Mevalonate pathway

See also[edit]