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Not to be confused with acetazolamide.
Acetohexamide ball-and-stick.png
Systematic (IUPAC) name
1-[(4-acetylbenzene)sulfonyl]-3-cyclohexylurea 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide
Clinical data
Trade names Dymelor
AHFS/ Micromedex Detailed Consumer Information
MedlinePlus a602021
Legal status
Pharmacokinetic data
Protein binding 90%
CAS number 968-81-0 YesY
ATC code A10BB31
PubChem CID 1989
DrugBank DB00414
ChemSpider 1912 YesY
KEGG D00219 YesY
ChEBI CHEBI:28052 YesY
Chemical data
Formula C15H20N2O4S 
Mol. mass 324.395 g/mol
 YesY (what is this?)  (verify)

Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.

Mechanism of action[edit]

Acetohexamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently.[1] The pancreas must produce insulin for this medication to work. For this reason, acetohexamide is not used to treat diabetes mellitus type 1.

metabolic reduction of acetohexamide into the active hypoglycemic metabolite S-(-)-hydroxyhexamide is carried out by cytochromes


Oral hypoglycemic drugs, including acetohexamide, have been associated with increased cardiovascular mortality. Talk to your doctor about the possible risks, benefits, and alternatives of using this drug for your condition.[2]



  1. ^ [1] - Metformin Side Effects
  2. ^ Medline Plus - Acetohexamide
  3. ^ Marshall, F. J.; Sigal, M. V.; Sullivan, H. R.; Cesnik, C.; Root, M. A. (1963). "Further Studies on N-Arylsulfonyl-N'-alkylureas". Journal of Medicinal Chemistry 6: 60–3. doi:10.1021/jm00337a014. PMID 14175624.  edit