The bodies of southern flounders are greatly compressed, with both eyes on the left side of their heads. The caudal fin is separate, and the pectoral fins are rudimentary or entirely absent; none of the fins has spines. The lateral line is straight and well-developed. The family varies considerably in size, from 11 cm (4.3 in) of Pseudomancopsetta andriashevi to the 57 cm (22 in) length of Neoachiropsetta milfordi.
Little is known of the habits of the species in this family.
- Paralichthys lethostigma, another species of a different order also sometimes called a "southern flounder"